Source:http://linkedlifedata.com/resource/pubmed/id/12598989
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2003-2-24
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| pubmed:abstractText |
The purpose of this study was to evaluate the diagnostic efficacy of iron-oxide-enhanced MRI vs CT during arterial portography (CTAP) and intraoperative ultrasound (IOUS) in detection of liver neoplasms. Seventeen patients with malignant focal liver lesions (liver metastases, n=7), hepatocellular carcinomas (HCC, n=9), and cholangiocellular carcinoma (CCC, n=1) underwent presurgical Resovist-enhanced MRI and CTAP. Two independent observers (A and B) assessed the blinded images of unenhanced and iron-oxide-enhanced MRI vs CTAP for the presence, number, and location of the liver lesions. These results were compared lesion by lesion and segment by segment with the results of intraoperative ultrasound ( n=17) serving as the reference standard. Eighty lesions were detected by intraoperative ultrasound in 17 patients. In comparison with IOUS (lesion-by-lesion analysis) the sensitivity was 86.8% for CTAP, 65% for combined unenhanced MR imaging, and 86.8% for combined Resovist-enhanced MRI as well as 86.8% for the combination of unenhanced and Resovist-enhanced MRI. Compared with the sensitivity of combined unenhanced MRI the sensitivity of CTAP as well as the sensitivity of combined Resovist-enhanced MRI was significantly higher (p<0.05). False-positive results were much higher in CTAP as compared with combined unenhanced and SPIO-enhanced MRI. Using the segment-by-segment analysis the specificity of combined unenhanced MRI with 100% (96.7-100%) as well as combined Resovist-enhanced MRI with 100% (96.7-100%) was significantly higher (p<0.05) in comparison with the specificity of CTAP with 91.1% (83.2-96.1%). The accuracy of combined unenhanced MRI was 100% (93.2-100%), combined Resovist-enhanced MRI 100% (93.6-100%) and of CTAP 85.2% (72.9-93.4%). In the detection of focal liver lesions iron-oxide-enhanced MR imaging is superior to unenhanced MRI and similar to CTAP.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Contrast Media,
http://linkedlifedata.com/resource/pubmed/chemical/Dextrans,
http://linkedlifedata.com/resource/pubmed/chemical/Ferumoxytol,
http://linkedlifedata.com/resource/pubmed/chemical/Iron,
http://linkedlifedata.com/resource/pubmed/chemical/Magnetite Nanoparticles,
http://linkedlifedata.com/resource/pubmed/chemical/Oxides,
http://linkedlifedata.com/resource/pubmed/chemical/ferumoxides
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
|
| pubmed:issn |
0938-7994
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| pubmed:author |
pubmed-author:BalzerThomasT,
pubmed-author:BlumeStefanS,
pubmed-author:FelixRolandR,
pubmed-author:FranzMartinaM,
pubmed-author:HammerstinglRenate MRM,
pubmed-author:LobeckHartmutH,
pubmed-author:NeuhausPeterP,
pubmed-author:PietschMichaelM,
pubmed-author:SchwarzWolframW,
pubmed-author:ShamsiKohkanK,
pubmed-author:VoglThomas JTJ,
pubmed-author:del TrediciKellyK
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| pubmed:issnType |
Print
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| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
262-72
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12598989-Adult,
pubmed-meshheading:12598989-Aged,
pubmed-meshheading:12598989-Aged, 80 and over,
pubmed-meshheading:12598989-Bile Duct Neoplasms,
pubmed-meshheading:12598989-Bile Ducts, Intrahepatic,
pubmed-meshheading:12598989-Carcinoma, Hepatocellular,
pubmed-meshheading:12598989-Contrast Media,
pubmed-meshheading:12598989-Dextrans,
pubmed-meshheading:12598989-Female,
pubmed-meshheading:12598989-Ferumoxytol,
pubmed-meshheading:12598989-Humans,
pubmed-meshheading:12598989-Image Enhancement,
pubmed-meshheading:12598989-Injections, Intravenous,
pubmed-meshheading:12598989-Iron,
pubmed-meshheading:12598989-Liver,
pubmed-meshheading:12598989-Liver Neoplasms,
pubmed-meshheading:12598989-Magnetic Resonance Imaging,
pubmed-meshheading:12598989-Magnetite Nanoparticles,
pubmed-meshheading:12598989-Male,
pubmed-meshheading:12598989-Middle Aged,
pubmed-meshheading:12598989-Observer Variation,
pubmed-meshheading:12598989-Oxides,
pubmed-meshheading:12598989-Portography,
pubmed-meshheading:12598989-Sensitivity and Specificity,
pubmed-meshheading:12598989-Tomography, Spiral Computed,
pubmed-meshheading:12598989-Ultrasonography
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| pubmed:year |
2003
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| pubmed:articleTitle |
Preoperative evaluation of malignant liver tumors: comparison of unenhanced and SPIO (Resovist)-enhanced MR imaging with biphasic CTAP and intraoperative US.
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| pubmed:affiliation |
Department of Diagnostic and Interventional Radiology, Johann Wolfgang Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. t.vogl@em.uni-frankfurt.de
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Evaluation Studies,
Clinical Trial, Phase III
|