Source:http://linkedlifedata.com/resource/pubmed/id/12598856
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2003-2-24
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pubmed:abstractText |
Intense immunosuppression plus stem-cell transplantation (SCT) has emerged as a new treatment modality for patients with refractory, severe rheumatic autoimmune disease. Its rationale is based on eliminating autoaggressive lymphocytes by lympho- or myeloablative conditioning followed by stem-cell rescue. Preclinical studies in animal models of autoimmune disease and observations in patients with rheumatoid arthritis (RA) who were cured after allogeneic bone marrow transplantation for concomitant hematologic malignancy have provided support for the concept.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
1073-2748
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
57-65
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12598856-Arthritis, Juvenile Rheumatoid,
pubmed-meshheading:12598856-Arthritis, Rheumatoid,
pubmed-meshheading:12598856-Humans,
pubmed-meshheading:12598856-Immunosuppression,
pubmed-meshheading:12598856-Lupus Erythematosus, Systemic,
pubmed-meshheading:12598856-Scleroderma, Systemic,
pubmed-meshheading:12598856-Stem Cell Transplantation
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pubmed:articleTitle |
Intense immunosuppression and stem-cell transplantation for patients with severe rheumatic autoimmune disease: a review.
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pubmed:affiliation |
Department of Rheumatology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands. j.m.van_laar@lumc.nl
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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