Source:http://linkedlifedata.com/resource/pubmed/id/12598490
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2003-7-9
|
| pubmed:abstractText |
Viral infections induce excess non-rapid eye movement sleep (NREMS) in mice. Growth hormone-releasing hormone receptor (GHRH receptor) was previously identified as a candidate gene responsible for NREMS responses to influenza challenge in mice. The dwarf lit/lit mouse with a nonfunctional GHRH receptor was used to assess the role of the GHRH receptor in viral-induced NREMS. After influenza A virus infection the duration and intensity [electroencephalogram (EEG) delta power] of NREMS increased in heterozygous mice with the normal phenotype, whereas NREMS and EEG delta power decreased in homozygous lit/lit mice. Lit/lit mice developed a pathological state with EEG slow waves and enhanced muscle tone. Other influenza-induced responses (decreases in rapid eye movement sleep, changes in the EEG high-frequency bands during the various stages of vigilance, hypothermia, and decreased motor activity) did not differ between the heterozygous and lit/lit mice. GH replacement failed to normalize the NREMS responses in the lit/lit mice after influenza inoculation. Decreases in NREMS paralleled hypothermia in the lit/lit mice. Lung virus levels were similar in the two mouse strains. Lit/lit mice had a higher death rate after influenza challenge than the heterozygotes. In conclusion, GHRH signaling is involved in the NREMS response to influenza infection.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Growth Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neuropeptide,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Pituitary...,
http://linkedlifedata.com/resource/pubmed/chemical/somatotropin releasing hormone...
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
8750-7587
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
95
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
460-8
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:12598490-Animals,
pubmed-meshheading:12598490-Body Temperature,
pubmed-meshheading:12598490-Brain,
pubmed-meshheading:12598490-Dwarfism,
pubmed-meshheading:12598490-Electroencephalography,
pubmed-meshheading:12598490-Growth Hormone,
pubmed-meshheading:12598490-Heterozygote,
pubmed-meshheading:12598490-Homozygote,
pubmed-meshheading:12598490-Influenza A virus,
pubmed-meshheading:12598490-Infusion Pumps,
pubmed-meshheading:12598490-Insulin-Like Growth Factor I,
pubmed-meshheading:12598490-Lung,
pubmed-meshheading:12598490-Male,
pubmed-meshheading:12598490-Mice,
pubmed-meshheading:12598490-Mice, Inbred C57BL,
pubmed-meshheading:12598490-Orthomyxoviridae Infections,
pubmed-meshheading:12598490-Point Mutation,
pubmed-meshheading:12598490-Receptors, Neuropeptide,
pubmed-meshheading:12598490-Receptors, Pituitary Hormone-Regulating Hormone,
pubmed-meshheading:12598490-Sleep,
pubmed-meshheading:12598490-Sleep, REM,
pubmed-meshheading:12598490-Viral Load
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| pubmed:year |
2003
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| pubmed:articleTitle |
Alterations in EEG activity and sleep after influenza viral infection in GHRH receptor-deficient mice.
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| pubmed:affiliation |
Department of Veterinary and Comparative Anatomy and Pphysiology, Washington State University, College of Veterinary Medicine, Pullman, WA 99164-6520, USA.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|