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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-2-21
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pubmed:abstractText |
Lymphatic filariasis is a tropical disease caused by the nematode parasites Wuchereria bancrofti and Brugia malayi. Whereas the protective potential of T lymphocytes in filarial infection is well documented, investigation of the role of B lymphocytes in antifilarial immunity has been neglected. In this communication, we examine the role of B lymphocytes in antifilarial immunity, using Brugia pahangi infections in the murine peritoneal cavity as a model. We find that B lymphocytes are required for clearance of primary and challenge infections with B. pahangi third-stage larvae (L3). We assessed the protective potential of peritoneal B lymphocytes by adoptive transfer experiments. Primed but not naïve peritoneal B cells from wild-type mice that had been immunized with B. pahangi L3 protected athymic recipients from challenge infection. We evaluated possible mechanisms by which B cells mediate protection. Comparisons of cytokine mRNA expression between B-lymphocyte-deficient and immunocompetent mice following B. pahangi infection suggest that B cells are required for the early production of Th2-type cytokines by peritoneal cells. In addition, B-cell-deficient mice demonstrate a defect in inflammatory cell recruitment to the peritoneal cavity following B. pahangi infection. The data demonstrate a critical role of B lymphocytes in antifilarial immunity in naïve mice and in the memory response in primed mice.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-10684864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-10768970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-10837417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-11101868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-11138639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-11395916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-11522405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-11598043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-11598082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-11705956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-11836389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-11937552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-12128050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-1910207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-1997651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-2868637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-3128606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-3688312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-4711663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-6110323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-6118038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-6605421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-6967111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-7119985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-7542801,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-8098731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-8932766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-8943203,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/12595454-9886405
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1370-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12595454-Adoptive Transfer,
pubmed-meshheading:12595454-Animals,
pubmed-meshheading:12595454-Antibodies, Helminth,
pubmed-meshheading:12595454-Antigen Presentation,
pubmed-meshheading:12595454-B-Lymphocytes,
pubmed-meshheading:12595454-Brugia pahangi,
pubmed-meshheading:12595454-Cytokines,
pubmed-meshheading:12595454-Filariasis,
pubmed-meshheading:12595454-Male,
pubmed-meshheading:12595454-Mice,
pubmed-meshheading:12595454-Mice, Inbred BALB C,
pubmed-meshheading:12595454-Mice, Nude,
pubmed-meshheading:12595454-Peritoneal Cavity
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pubmed:year |
2003
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pubmed:articleTitle |
Primed peritoneal B lymphocytes are sufficient to transfer protection against Brugia pahangi infection in mice.
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pubmed:affiliation |
Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut 06030-3105, USA.
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pubmed:publicationType |
Journal Article
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