Source:http://linkedlifedata.com/resource/pubmed/id/12595199
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2003-2-21
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| pubmed:abstractText |
The value of functional MR Imaging (fMRI) in assessing language lateralization in epileptic patients candidate for surgical treatment is increasingly recognized. However few data are available for left-handed patients. Moreover determining factors for atypical dominance in patients investigated with contemporary imaging have not been reported. We studied 20 patients (14 males, 6 females; 9 right handed, 11 left handed) aged from 9 to 48 years, investigated for intractable partial epilepsy. Epileptic focus location was temporal in 14 cases, extratemporal in 6, and lateralized in the left hemisphere in 11/20. Hemispheric dominance for language was evaluated by both Wada test and fMRI using a silent word generation paradigm in all patients. Furthermore, a postictal speech test was performed in 15 patients. An fMRI language lateralization index was calculated from the number of activated pixels (Student's t test, P < 0.0001) in the right and left hemispheres. The Wada test showed a right hemispheric dominance in 8 patients (6 were left handed and 2 right handed) and a left hemispheric dominance in 12 patients (5 were left handed and 7 right handed). These results were concordant with clinical postictal examination in 11/15 patients (73%). Clinical status did not allow a conclusion about hemispheric dominance for the remaining 4 patients. FMRI was concordant with the Wada test in 19/20 cases. For one left-handed patient, fMRI showed bilateral activation, whereas the Wada test demonstrated a right hemispheric dominance. Right language lateralization was significantly correlated with left lateralized epilepsy (P < 0.05) but was not correlated with age at epilepsy onset, early brain injury (before 6 years), and lobar localization of epileptogenic focus. However the lack of a significant relationship between these factors and atypical language lateralization may be related to the small sample size.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
1053-8119
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| pubmed:author |
pubmed-author:Aït-AmeurAA,
pubmed-author:Baudoin-ChialSS,
pubmed-author:ChassouxFF,
pubmed-author:ChodkiewiczJ PJP,
pubmed-author:CordolianiY SYS,
pubmed-author:DevauxBB,
pubmed-author:Godon-HardySS,
pubmed-author:LandreEE,
pubmed-author:LevequeCC,
pubmed-author:MannMM,
pubmed-author:NiocheCC,
pubmed-author:SabbahPP,
pubmed-author:SarrazinJ LJL
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| pubmed:issnType |
Print
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| pubmed:volume |
18
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
460-7
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12595199-Adolescent,
pubmed-meshheading:12595199-Adult,
pubmed-meshheading:12595199-Amobarbital,
pubmed-meshheading:12595199-Anomia,
pubmed-meshheading:12595199-Brain Mapping,
pubmed-meshheading:12595199-Child,
pubmed-meshheading:12595199-Dominance, Cerebral,
pubmed-meshheading:12595199-Electroencephalography,
pubmed-meshheading:12595199-Epilepsy, Temporal Lobe,
pubmed-meshheading:12595199-Female,
pubmed-meshheading:12595199-Humans,
pubmed-meshheading:12595199-Image Processing, Computer-Assisted,
pubmed-meshheading:12595199-Language Tests,
pubmed-meshheading:12595199-Magnetic Resonance Imaging,
pubmed-meshheading:12595199-Male,
pubmed-meshheading:12595199-Middle Aged,
pubmed-meshheading:12595199-Reading,
pubmed-meshheading:12595199-Sensitivity and Specificity,
pubmed-meshheading:12595199-Speech Perception,
pubmed-meshheading:12595199-Verbal Behavior
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| pubmed:year |
2003
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| pubmed:articleTitle |
Functional MR imaging in assessment of language dominance in epileptic patients.
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| pubmed:affiliation |
Service de Radiologie, Hôpital d'Instruction des Armées du Val de Grâce, 74 Boulevard Port Royal, F-75230 Paris, France. sabbah@mail.pf
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| pubmed:publicationType |
Journal Article
|