Linked Life Data

12595183

Source:http://linkedlifedata.com/resource/pubmed/id/12595183

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-2-21
pubmed:abstractText
Recent research has suggested that childhood onset of localization-related (focal) temporal lobe epilepsy is associated with a generalized adverse effect on cognition and brain structure, especially cerebral white matter volume. This study examined the neurodevelopmental impact of childhood onset epilepsy on corpus callosum volume and the cognitive consequences of reduced cerebral connectivity. Healthy controls (n = 15) and patients with temporal lobe epilepsy (n = 32) were matched on gender and handedness, and childhood and adult onset epilepsy groups were matched on duration of epilepsy (mean = 19 years) but varied in neurodevelopmental age at onset of recurrent seizures. Results showed that childhood onset of temporal lobe epilepsy was associated with significant volumetric reduction of the corpus callosum compared to both late onset and healthy controls, with the latter two groups not differing from one another. The volumetric loss was most evident in posterior followed by anterior corpus callosum. Volumetric reduction of the corpus callosum in temporal lobe epilepsy was of clinical significance with smaller volumes associated with poorer performance on measures of nonverbal problem solving, immediate memory, speeded complex psychomotor ability and fine motor dexterity. These findings indicate that childhood onset of temporal lobe epilepsy is associated with an adverse neurodevelopmental impact on brain connectivity which is of clinical consequence and theoretical interest.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1053-8119
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
284-92
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Neurodevelopmental vulnerability of the corpus callosum to childhood onset localization-related epilepsy.
pubmed:affiliation
Department of Neurology, University of Wisconsin, Madison, WI 53792, USA. hermann@neurology.wisc.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.