Source:http://linkedlifedata.com/resource/pubmed/id/12594814
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2003-2-20
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| pubmed:abstractText |
Recent studies have demonstrated that peroxisome proliferator activator-receptors(PPAR)-gamma is expressed in various cancer tissues and its ligand induces growth arrest of these cancer cells through apoptosis. In our study, we investigated the expression of PPAR-alpha, beta and gamma in human bladder tumor (BT) and normal bladder (NB) tissues as well as the effects of PPAR-gamma ligands. Specimens were obtained from 170 patients with BT and 20 with NB. The expressions were investigated using RT-PCR and immunohistochemical methods. We also investigated the inhibitory effect of PPAR-gamma ligands on BT-derived cell line. Immunoreactive PPAR-alpha and -beta were significantly apparent in both BT and NB tissues. Although no marked expression of PPAR-gamma was observed in NB tissue, significant expression was found in BT tissue. The extent and intensity of immunoreactive PPAR-gamma polypeptides in BT cells were statistically much greater than those of NB cells. Correlation between PPAR-gamma expression and tissue type or progression of bladder cancer was observed; PPAR-gamma expression was higher in G3 of bladder cancer than in G1 and was higher in advanced than in early cancer. PPAR-gamma agonists, troglitazone and 15-deoxy-Delta(12, 14)-prostaglandin J(2) inhibited the growth of the BT cells. PPAR-gamma is expressed in bladder tumor, and results suggest that PPAR-gamma ligands may mediate potent antiproliferative effects against BT cells. Thus, PPAR-gamma has the ability to become a new target in treatment of bladder tumor.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chromans,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazolidinediones,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/troglitazone
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
0020-7136
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| pubmed:author |
pubmed-author:HaseTaroT,
pubmed-author:KawahitoYutakaY,
pubmed-author:MatsuyamaMasahideM,
pubmed-author:MitsuhashiMakotoM,
pubmed-author:NakataniTatsuyaT,
pubmed-author:SanoHajimeH,
pubmed-author:SegawaYoshihiroY,
pubmed-author:TsuchidaKennjiK,
pubmed-author:WadaSeijiS,
pubmed-author:YoshimuraRikioR
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| pubmed:copyrightInfo |
Copyright 2003 Wiley-Liss, Inc.
|
| pubmed:issnType |
Print
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| pubmed:day |
1
|
| pubmed:volume |
104
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
597-602
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| pubmed:dateRevised |
2007-7-24
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| pubmed:meshHeading |
pubmed-meshheading:12594814-Aged,
pubmed-meshheading:12594814-Cell Division,
pubmed-meshheading:12594814-Chromans,
pubmed-meshheading:12594814-Female,
pubmed-meshheading:12594814-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:12594814-Humans,
pubmed-meshheading:12594814-Immunohistochemistry,
pubmed-meshheading:12594814-Ligands,
pubmed-meshheading:12594814-Male,
pubmed-meshheading:12594814-Middle Aged,
pubmed-meshheading:12594814-Neoplasm Staging,
pubmed-meshheading:12594814-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:12594814-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12594814-Thiazoles,
pubmed-meshheading:12594814-Thiazolidinediones,
pubmed-meshheading:12594814-Transcription Factors,
pubmed-meshheading:12594814-Urinary Bladder,
pubmed-meshheading:12594814-Urinary Bladder Neoplasms
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| pubmed:year |
2003
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| pubmed:articleTitle |
Expression of peroxisome proliferator-activated receptors (PPARs) in human urinary bladder carcinoma and growth inhibition by its agonists.
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| pubmed:affiliation |
Department of Urology, Osaka City University Medical School, Osaka, Japan. jasmin@med.osaka-cu.ac.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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