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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0039194,
umls-concept:C0185117,
umls-concept:C0242381,
umls-concept:C0253023,
umls-concept:C0439097,
umls-concept:C1547348,
umls-concept:C1550315,
umls-concept:C1552644,
umls-concept:C1705241,
umls-concept:C1823153,
umls-concept:C2349976,
umls-concept:C2911684
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pubmed:issue |
5
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pubmed:dateCreated |
2003-2-20
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pubmed:abstractText |
Gamma delta T cells accumulate at epithelial barriers and at sites of inflammation in various infectious and autoimmune diseases, yet little is understood about the function of tissue-infiltrating gamma delta T cells. We observe that gamma delta T cells of the V delta 1 subset accumulate in synovial fluid of human Lyme arthritis and are intensely cytolytic toward a wide array of target cells. Particularly striking is that the cytolytic activity is highly prolonged, lasting for at least 3 wk after stimulation of the gamma delta T cells with Borrelia burgdorferi. Cytolysis is largely Fas dependent and results from very high and prolonged expression of surface Fas ligand, which is transcriptionally regulated. This also manifests in a substantial level of self-induced apoptosis of the gamma delta T cells. In this capacity, certain gamma delta T cell subsets may serve as cytolytic sentinels at sites of inflammation, and perhaps at epithelial barriers.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/FASLG protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fas Ligand Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Fasl protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Perforin,
http://linkedlifedata.com/resource/pubmed/chemical/Pore Forming Cytotoxic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
170
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2702-10
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12594300-Animals,
pubmed-meshheading:12594300-Antigens, CD95,
pubmed-meshheading:12594300-Apoptosis,
pubmed-meshheading:12594300-Borrelia burgdorferi,
pubmed-meshheading:12594300-Cell Division,
pubmed-meshheading:12594300-Cell Line,
pubmed-meshheading:12594300-Clone Cells,
pubmed-meshheading:12594300-Cytotoxicity, Immunologic,
pubmed-meshheading:12594300-Fas Ligand Protein,
pubmed-meshheading:12594300-Humans,
pubmed-meshheading:12594300-Ligands,
pubmed-meshheading:12594300-Lyme Disease,
pubmed-meshheading:12594300-Membrane Glycoproteins,
pubmed-meshheading:12594300-Mice,
pubmed-meshheading:12594300-Mice, Inbred BALB C,
pubmed-meshheading:12594300-Perforin,
pubmed-meshheading:12594300-Pore Forming Cytotoxic Proteins,
pubmed-meshheading:12594300-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:12594300-Synovial Fluid,
pubmed-meshheading:12594300-T-Lymphocyte Subsets,
pubmed-meshheading:12594300-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:12594300-Transcription, Genetic
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pubmed:year |
2003
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pubmed:articleTitle |
High expression of Fas ligand by synovial fluid-derived gamma delta T cells in Lyme arthritis.
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pubmed:affiliation |
Department of Medicine (Immunobiology), The University of Vermont College of Medicine, Burlington, VT 05405, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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