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pubmed-article:12593713pubmed:abstractTextPreviously, we have documented that lung injury after trauma-hemorrhagic shock (T/HS) is related to gut injury and that females are more resistant to T/HS-induced lung injury than males. However, it is not known if the estrus cycle stage at the time of injury influences the female rat's resistance to T/HS-induced lung injury. Therefore, the goal of this study was to determine if the protective effect of the female gender on lung injury after T/HS is estrus cycle stage-specific. To test this hypothesis, female rats were subjected to trauma (laparotomy) and hemorrhagic shock (T/HS) during different stages of the estrus cycle. Female animals subjected to trauma with sham hemorrhagic shock served as the control.lld:pubmed
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pubmed-article:12593713pubmed:articleTitleThe female gender protects against pulmonary injury after trauma hemorrhagic shock.lld:pubmed
pubmed-article:12593713pubmed:affiliationDepartment of Surgery, New Jersey Medical School, Newark, New Jersey 07103, USA.lld:pubmed
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