Linked Life Data

12591

Source:http://linkedlifedata.com/resource/pubmed/id/12591

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1977-2-26
pubmed:abstractText
Physical studies carried out on a range of protein and clotting factor adsorbents revealed marked morphological and charge differences. Their appearance in the scanning electron microscope could be used to classify the insoluble precipitates, calcijm phosphate, barium sulphate and citrate, as either amorphorous or crystalline. Surface charge is difficult to define but the present studies on the sparingly-soluble salts, based on calcium and barium, have revealed that they can be subdivided on the basis of the presence or absence of a charge reversal point in the pH-mobility curve. The anion component appeared to determine this characteristic; it was noted that phosphate and citrate ions had a marked effect and gave a biased negative potential at all pH values. We concluded that where a divalent cation is cohabiting with a trivalent anion, the greater potential-determining ability of the latter will dominate the overall charge at the surface of a particle, even below pH7 and the absence of a positive potential gives a monophasic pH-mobility curve. Differences in both the physical appearance and electrophoretic mobility of the adsorbents studied reflect the wide variation in their chemical composition, especially among the various forms of calcium phosphate which, unlike barium sulphate, can include substituted ions such as hydroxyl, in their crystal lattice. The definition of these characteristics allows their behaviour towards clotting factors to be more easily predicted.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0340-6245
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
60-70
pubmed:dateRevised
2000-12-18
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Scanning electron microscopic and electrophoretic studies on clotting factor adsorbents.
pubmed:publicationType
Journal Article