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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2003-2-19
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pubmed:abstractText |
Increased oxidative stress and dysregulation of nitric oxide have been implicated in the cardiotoxicity of doxorubicin (DOX), a commonly used antitumor agent. Peroxynitrite is a reactive oxidant produced from nitric oxide and superoxide in various forms of cardiac injury. Using a novel metalloporphyrinic peroxynitrite decomposition catalyst, FP15, and nitric oxide synthase inhibitors or knockout mice, we now delineate the pathogenetic role of peroxynitrite in rodent models of DOX-induced cardiac dysfunction.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Creatine Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Doxorubicin,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/FeCl...,
http://linkedlifedata.com/resource/pubmed/chemical/L-Lactate Dehydrogenase,
http://linkedlifedata.com/resource/pubmed/chemical/Metalloporphyrins,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Nos3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Peroxynitrous Acid
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:BaiPéterP,
pubmed-author:DebAmitabhaA,
pubmed-author:GrovesJohn TJT,
pubmed-author:KaminskiPawel MPM,
pubmed-author:LiaudetLucasL,
pubmed-author:MableyJon GJG,
pubmed-author:PacherPálP,
pubmed-author:SzabóCsabaC,
pubmed-author:SzabóEvaE,
pubmed-author:UngváriZoltánZ,
pubmed-author:VirágLászlóL,
pubmed-author:WolinMichael SMS
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pubmed:issnType |
Electronic
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pubmed:day |
18
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
896-904
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12591762-Acute Disease,
pubmed-meshheading:12591762-Animals,
pubmed-meshheading:12591762-Catalysis,
pubmed-meshheading:12591762-Chronic Disease,
pubmed-meshheading:12591762-Creatine Kinase,
pubmed-meshheading:12591762-Disease Models, Animal,
pubmed-meshheading:12591762-Doxorubicin,
pubmed-meshheading:12591762-Enzyme Inhibitors,
pubmed-meshheading:12591762-Heart,
pubmed-meshheading:12591762-Heart Failure,
pubmed-meshheading:12591762-L-Lactate Dehydrogenase,
pubmed-meshheading:12591762-Male,
pubmed-meshheading:12591762-Metalloporphyrins,
pubmed-meshheading:12591762-Mice,
pubmed-meshheading:12591762-Mice, Inbred BALB C,
pubmed-meshheading:12591762-Mice, Inbred C57BL,
pubmed-meshheading:12591762-Mice, Knockout,
pubmed-meshheading:12591762-Nitric Oxide Synthase,
pubmed-meshheading:12591762-Nitric Oxide Synthase Type II,
pubmed-meshheading:12591762-Nitric Oxide Synthase Type III,
pubmed-meshheading:12591762-Oxidative Stress,
pubmed-meshheading:12591762-Peroxynitrous Acid,
pubmed-meshheading:12591762-Survival Rate
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pubmed:year |
2003
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pubmed:articleTitle |
Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction.
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pubmed:affiliation |
Inotek Pharmaceuticals Corp, Beverly, Mass 01915, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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