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rdf:type |
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lifeskim:mentions |
umls-concept:C0010453,
umls-concept:C0017262,
umls-concept:C0021289,
umls-concept:C0021469,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0075233,
umls-concept:C0225828,
umls-concept:C1144709,
umls-concept:C1280500,
umls-concept:C2333889
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pubmed:issue |
6
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pubmed:dateCreated |
2003-2-19
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pubmed:abstractText |
Although previously thought to be synthesized solely in adrenal cortex, we have recently showed that aldosterone is also produced in and the expression of CYP11B2 mRNA was induced in the failing or hypertensive human ventricle. Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are cardiac hormones with wide biological effects, including inhibition of renin and aldosterone production. We hypothesized that natriuretic peptides reduce the expression of CYP11B2 mRNA in the heart.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:HaradaEisakuE,
pubmed-author:HaradaMasakiM,
pubmed-author:ItoTeruhikoT,
pubmed-author:KuriharaHirokiH,
pubmed-author:MizunoYujiY,
pubmed-author:NakamuraShotaS,
pubmed-author:NakaoKazuwaK,
pubmed-author:NakayamaMasafumiM,
pubmed-author:OgawaHisaoH,
pubmed-author:SaitoYoshihikoY,
pubmed-author:ShimasakiYukioY,
pubmed-author:YamamuroMegumiM,
pubmed-author:YasueHirofumiH,
pubmed-author:YoshimuraMichihiroM
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pubmed:issnType |
Electronic
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pubmed:day |
18
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
807-10
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12591748-Aldosterone Synthase,
pubmed-meshheading:12591748-Angiotensin II,
pubmed-meshheading:12591748-Animals,
pubmed-meshheading:12591748-Animals, Newborn,
pubmed-meshheading:12591748-Atrial Natriuretic Factor,
pubmed-meshheading:12591748-Cells, Cultured,
pubmed-meshheading:12591748-Coculture Techniques,
pubmed-meshheading:12591748-Cyclic GMP,
pubmed-meshheading:12591748-Gene Expression,
pubmed-meshheading:12591748-Myocytes, Cardiac,
pubmed-meshheading:12591748-Natriuretic Peptide, Brain,
pubmed-meshheading:12591748-Polysaccharides,
pubmed-meshheading:12591748-RNA, Messenger,
pubmed-meshheading:12591748-Rats,
pubmed-meshheading:12591748-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2003
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pubmed:articleTitle |
Inhibitory effect of natriuretic peptides on aldosterone synthase gene expression in cultured neonatal rat cardiocytes.
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pubmed:affiliation |
Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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