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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-2-19
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pubmed:databankReference |
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pubmed:abstractText |
Plexins belonging to the plexin-A subfamily form complexes with neuropilins and propagate signals of class 3 semaphorins into neurons, even though they do not directly bind the semaphorins. In this study, we identified a new member of the plexin-A subfamily in the mice, plexin-A4, and showed that it was expressed in the developing nervous system with a pattern different to that of other members of the plexin-A subfamily (plexin-A1, plexin-A2 and plexin-A3). COS-7 cells coexpressing plexin-A4 with neuropilin-1 were induced to contract by Sema3A, a member of the class 3 semaphorin. Ectopic expression of plexin-A4 in mitral cells that are originally insensitive to Sema3A resulted in the collapse of growth cones in the presence of Sema3A. These results suggest that plexin-A4 plays a role in the propagation of Sema3A activities.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropilin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Plxna1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Plxna4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Sema3a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Semaphorin-3A
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0925-4773
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
120
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
385-96
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12591607-Amino Acid Sequence,
pubmed-meshheading:12591607-Animals,
pubmed-meshheading:12591607-Axons,
pubmed-meshheading:12591607-Brain,
pubmed-meshheading:12591607-COS Cells,
pubmed-meshheading:12591607-Carrier Proteins,
pubmed-meshheading:12591607-Cloning, Molecular,
pubmed-meshheading:12591607-Ganglia,
pubmed-meshheading:12591607-Ganglia, Sensory,
pubmed-meshheading:12591607-Gene Expression Regulation, Developmental,
pubmed-meshheading:12591607-Growth Cones,
pubmed-meshheading:12591607-Mice,
pubmed-meshheading:12591607-Mice, Inbred ICR,
pubmed-meshheading:12591607-Molecular Sequence Data,
pubmed-meshheading:12591607-Multigene Family,
pubmed-meshheading:12591607-Mutation,
pubmed-meshheading:12591607-Nerve Tissue Proteins,
pubmed-meshheading:12591607-Nervous System,
pubmed-meshheading:12591607-Neuropilin-1,
pubmed-meshheading:12591607-Olfactory Bulb,
pubmed-meshheading:12591607-Organ of Corti,
pubmed-meshheading:12591607-Receptors, Cell Surface,
pubmed-meshheading:12591607-Retina,
pubmed-meshheading:12591607-Semaphorin-3A
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pubmed:year |
2003
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pubmed:articleTitle |
Identification and characterization of a novel mouse plexin, plexin-A4.
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pubmed:affiliation |
Group of Developmental Neurobiology, Nagoya University Graduate School of Science, Chikusa-ku, Nagoya 464-8602, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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