Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-2-19
pubmed:abstractText
What is the functional significance of generating a burst of spikes, as opposed to a single spike? A dominant point of view is that bursts are needed to increase the reliability of communication between neurons. Here, we discuss the alternative, but complementary, hypothesis: bursts with specific resonant interspike frequencies are more likely to cause a postsynaptic cell to fire than are bursts with higher or lower frequencies. Such a frequency preference might occur at the level of individual synapses because of the interplay between short-term synaptic depression and facilitation, or at the postsynaptic cell level because of subthreshold membrane potential oscillations and resonance. As a result, the same burst could resonate for some synapses or cells and not resonate for others, depending on their natural resonance frequencies. This observation suggests that, in addition to increasing reliability of synaptic transmission, bursts of action potentials might provide effective mechanisms for selective communication between neurons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0166-2236
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
161-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Bursts as a unit of neural information: selective communication via resonance.
pubmed:affiliation
The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA. eugene.izhikevich@nsi.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Review, Research Support, Non-U.S. Gov't