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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2003-2-19
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pubmed:abstractText |
Previous studies revealed that cholinergic neurons possessing long axons are extremely sensitive to ethylcholine aziridinium ion (AF64A) administration [Neuropharmacology 31 (1992) 397]. In the present paper we examined the effect of AF64A on the cholinergic elements of the cingulum bundle. Seven days after AF64A administration choline acetyltransferase (ChAT)-immunoreactive fibers were extensively damaged on the dorsal part of cingulum bundle. These findings are the first reporting damage by AF64A to this brain region.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
965
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
295-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12591151-Animals,
pubmed-meshheading:12591151-Aziridines,
pubmed-meshheading:12591151-Choline,
pubmed-meshheading:12591151-Choline O-Acetyltransferase,
pubmed-meshheading:12591151-Cholinergic Fibers,
pubmed-meshheading:12591151-Dose-Response Relationship, Drug,
pubmed-meshheading:12591151-Gyrus Cinguli,
pubmed-meshheading:12591151-Male,
pubmed-meshheading:12591151-Rats,
pubmed-meshheading:12591151-Rats, Inbred F344,
pubmed-meshheading:12591151-Toxins, Biological
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pubmed:year |
2003
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pubmed:articleTitle |
Dose-dependent effect of cholinotoxin AF64A on the cholinergic elements of the cingulum bundle in rat.
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pubmed:affiliation |
Department of Pharmacology and Experimental Therapeutics, Loyola University Chicago, Strich School of Medicine, 2160 South First Avenue, Maywood, IL 60153, USA. bdudas@lumc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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