| pubmed-article:12590942 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12590942 | lifeskim:mentions | umls-concept:C1334290 | lld:lifeskim |
| pubmed-article:12590942 | lifeskim:mentions | umls-concept:C1334291 | lld:lifeskim |
| pubmed-article:12590942 | lifeskim:mentions | umls-concept:C1367307 | lld:lifeskim |
| pubmed-article:12590942 | lifeskim:mentions | umls-concept:C0814990 | lld:lifeskim |
| pubmed-article:12590942 | lifeskim:mentions | umls-concept:C0040624 | lld:lifeskim |
| pubmed-article:12590942 | lifeskim:mentions | umls-concept:C1417815 | lld:lifeskim |
| pubmed-article:12590942 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:12590942 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:12590942 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:12590942 | pubmed:dateCreated | 2003-2-19 | lld:pubmed |
| pubmed-article:12590942 | pubmed:abstractText | Neuropeptide Y (NPY) plays an important role in the central and sympathetic regulation of food intake and blood pressure. Although the NPY gene expression is regulated by a number of agents such as leptin, the mechanism responsible for leptin-induced regulation of the transcription of the NPY gene remains to be explored. In this study, the NPY gene promoter was transactivated by leptin in N18TG2, NG108-15 and PC12 cells which expressed the functional leptin receptor. The long isoform of leptin receptor (OB-Rb) could induce the transactivation, but the C-terminal truncated form (OB-Ra) could not. When dominant negative type of STAT3, JAK1 or JAK2 and was co-expressed, the leptin-induced transactivation was suppressed almost completely. The leptin-response element which confers NPY gene transactivation by leptin was determined in the 221-bp region of rat NPY gene promoter (-553/-335), where two STAT3-binding site-like elements (TCCAGTA) exist. These results indicated that activation of JAK1, JAK2 and STAT3 is necessary for leptin-induced transactivation of NPY gene through the leptin-response element in these neural cells. | lld:pubmed |
| pubmed-article:12590942 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12590942 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12590942 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12590942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12590942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12590942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12590942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12590942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12590942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12590942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12590942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12590942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12590942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12590942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12590942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12590942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12590942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12590942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12590942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12590942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12590942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12590942 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12590942 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12590942 | pubmed:issn | 0197-0186 | lld:pubmed |
| pubmed-article:12590942 | pubmed:author | pubmed-author:LinN SNS | lld:pubmed |
| pubmed-article:12590942 | pubmed:author | pubmed-author:AkiraShizuoS | lld:pubmed |
| pubmed-article:12590942 | pubmed:author | pubmed-author:HiguchiHirosh... | lld:pubmed |
| pubmed-article:12590942 | pubmed:author | pubmed-author:MuraokaOsamuO | lld:pubmed |
| pubmed-article:12590942 | pubmed:author | pubmed-author:YamaguchiTsuy... | lld:pubmed |
| pubmed-article:12590942 | pubmed:author | pubmed-author:TsurumakiTats... | lld:pubmed |
| pubmed-article:12590942 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12590942 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:12590942 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12590942 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12590942 | pubmed:pagination | 591-601 | lld:pubmed |
| pubmed-article:12590942 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:12590942 | pubmed:meshHeading | pubmed-meshheading:12590942... | lld:pubmed |
| pubmed-article:12590942 | pubmed:meshHeading | pubmed-meshheading:12590942... | lld:pubmed |
| pubmed-article:12590942 | pubmed:meshHeading | pubmed-meshheading:12590942... | lld:pubmed |
| pubmed-article:12590942 | pubmed:meshHeading | pubmed-meshheading:12590942... | lld:pubmed |
| pubmed-article:12590942 | pubmed:meshHeading | pubmed-meshheading:12590942... | lld:pubmed |
| pubmed-article:12590942 | pubmed:meshHeading | pubmed-meshheading:12590942... | lld:pubmed |
| pubmed-article:12590942 | pubmed:meshHeading | pubmed-meshheading:12590942... | lld:pubmed |
| pubmed-article:12590942 | pubmed:meshHeading | pubmed-meshheading:12590942... | lld:pubmed |
| pubmed-article:12590942 | pubmed:meshHeading | pubmed-meshheading:12590942... | lld:pubmed |
| pubmed-article:12590942 | pubmed:meshHeading | pubmed-meshheading:12590942... | lld:pubmed |
| pubmed-article:12590942 | pubmed:meshHeading | pubmed-meshheading:12590942... | lld:pubmed |
| pubmed-article:12590942 | pubmed:meshHeading | pubmed-meshheading:12590942... | lld:pubmed |
| pubmed-article:12590942 | pubmed:meshHeading | pubmed-meshheading:12590942... | lld:pubmed |
| pubmed-article:12590942 | pubmed:meshHeading | pubmed-meshheading:12590942... | lld:pubmed |
| pubmed-article:12590942 | pubmed:meshHeading | pubmed-meshheading:12590942... | lld:pubmed |
| pubmed-article:12590942 | pubmed:meshHeading | pubmed-meshheading:12590942... | lld:pubmed |
| pubmed-article:12590942 | pubmed:meshHeading | pubmed-meshheading:12590942... | lld:pubmed |
| pubmed-article:12590942 | pubmed:meshHeading | pubmed-meshheading:12590942... | lld:pubmed |
| pubmed-article:12590942 | pubmed:meshHeading | pubmed-meshheading:12590942... | lld:pubmed |
| pubmed-article:12590942 | pubmed:meshHeading | pubmed-meshheading:12590942... | lld:pubmed |
| pubmed-article:12590942 | pubmed:meshHeading | pubmed-meshheading:12590942... | lld:pubmed |
| pubmed-article:12590942 | pubmed:meshHeading | pubmed-meshheading:12590942... | lld:pubmed |
| pubmed-article:12590942 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12590942 | pubmed:articleTitle | Leptin-induced transactivation of NPY gene promoter mediated by JAK1, JAK2 and STAT3 in the neural cell lines. | lld:pubmed |
| pubmed-article:12590942 | pubmed:affiliation | Division of Pharmacology, Department of Molecular Genetics, Course for Molecular and Cellular Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata 951 8510, Japan. | lld:pubmed |
| pubmed-article:12590942 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12590942 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3952 | entrezgene:pubmed | pubmed-article:12590942 | lld:entrezgene |
| entrez-gene:24604 | entrezgene:pubmed | pubmed-article:12590942 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12590942 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12590942 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12590942 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12590942 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12590942 | lld:pubmed |
