12590753

Source:http://linkedlifedata.com/resource/pubmed/id/12590753

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0014272, umls-concept:C0208973, umls-concept:C0326937, umls-concept:C0439662, umls-concept:C0439851, umls-concept:C0441655, umls-concept:C1517106, umls-concept:C1517892, umls-concept:C1552596, umls-concept:C1704666, umls-concept:C1947931, umls-concept:C2003847
pubmed:issue	1511
pubmed:dateCreated	2003-2-19
pubmed:abstractText	The activation of an immune response is beneficial for organisms but may also have costs that affect fitness. Documented immune costs include those associated with acquisition of special nutrients, as well as immunopathology or autoimmunity. Here, we test whether an experimental induction of the immune system with a non-pathological stimulant can elevate energy turnover in passerine birds. We injected phytohaemagglutinin (PHA), a commonly used mitogen that activates the cell-mediated immune response, into the wing web of house sparrows, Passer domesticus. We then examined energetic costs resulting from this immune activity and related those costs to other physiological activities. We found that PHA injection significantly elevated resting metabolic rate (RMR) of challenged sparrows relative to saline controls. We calculated the total cost of this immune activity to be ca. 4.20 kJ per day (29% RMR), which is equivalent to the cost of production of half of an egg (8.23 kJ egg(-1)) in this species. We suggest that immune activity in wild passerines increases energy expenditure, which in turn may influence important life-history characteristics such as clutch size, timing of breeding or the scheduling of moult.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/12590753-10518322, http://linkedlifedata.com/resource/pubmed/commentcorrection/12590753-10821610, http://linkedlifedata.com/resource/pubmed/commentcorrection/12590753-11021731, http://linkedlifedata.com/resource/pubmed/commentcorrection/12590753-11073456, http://linkedlifedata.com/resource/pubmed/commentcorrection/12590753-11375106, http://linkedlifedata.com/resource/pubmed/commentcorrection/12590753-14791422, http://linkedlifedata.com/resource/pubmed/commentcorrection/12590753-2443625, http://linkedlifedata.com/resource/pubmed/commentcorrection/12590753-2722141, http://linkedlifedata.com/resource/pubmed/commentcorrection/12590753-674011, http://linkedlifedata.com/resource/pubmed/commentcorrection/12590753-833070, http://linkedlifedata.com/resource/pubmed/commentcorrection/12590753-9374803, http://linkedlifedata.com/resource/pubmed/commentcorrection/12590753-9699312, http://linkedlifedata.com/resource/pubmed/commentcorrection/12590753-9753786
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101245157
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Phytohemagglutinins
pubmed:status	MEDLINE
pubmed:month	Jan
pubmed:issn	0962-8452
pubmed:author	pubmed-author:MartinLynn BLB2nd, pubmed-author:ScheuerleinAlexA, pubmed-author:WikelskiMartinM
pubmed:issnType	Print
pubmed:day	22
pubmed:volume	270
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	153-8
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:12590753-Animals, pubmed-meshheading:12590753-Energy Metabolism, pubmed-meshheading:12590753-Male, pubmed-meshheading:12590753-Phytohemagglutinins, pubmed-meshheading:12590753-Songbirds
pubmed:year	2003
pubmed:articleTitle	Immune activity elevates energy expenditure of house sparrows: a link between direct and indirect costs?
pubmed:affiliation	Department of Ecology, Ethology and Evolution, University of Illinois, Urbana-Champaign, Morrill Hall, Urbana-Champaign, IL 61801, USA. lbmartin@princeton.edu
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't