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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2003-2-19
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pubmed:abstractText |
The modeling, synthesis, and characterization of oligomers containing 2-aminoquinazolin-5-yl 2'-deoxynucleotide residues are reported. The 2-aminoquinazoline residues sequence specifically bind via Hoogsteen base pairing as a third strand in the center of the major groove at T:A base pair Watson-Crick duplex sequences. Evidence for the formation of a sequence specific three-stranded structure is based on thermal denaturation UV-vis and fluorescence studies. The novel 2-aminoquinazoline C-nucleotide is a component of a system designed to overcome the homopurine requirement for triple helix structures.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0002-7863
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
125
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2084-93
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12590536-Circular Dichroism,
pubmed-meshheading:12590536-DNA,
pubmed-meshheading:12590536-Glycosides,
pubmed-meshheading:12590536-Models, Molecular,
pubmed-meshheading:12590536-Nucleic Acid Conformation,
pubmed-meshheading:12590536-Oligonucleotides,
pubmed-meshheading:12590536-Organophosphorus Compounds,
pubmed-meshheading:12590536-Quinazolines,
pubmed-meshheading:12590536-Spectrometry, Fluorescence,
pubmed-meshheading:12590536-Spectrophotometry, Ultraviolet
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pubmed:year |
2003
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pubmed:articleTitle |
Design of triple helix forming C-glycoside molecules.
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pubmed:affiliation |
Eppley Institute for Research in Cancer, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198-6805, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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