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rdf:type |
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lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0016057,
umls-concept:C0037083,
umls-concept:C0162638,
umls-concept:C0205263,
umls-concept:C0205548,
umls-concept:C0220802,
umls-concept:C0332291,
umls-concept:C0805732,
umls-concept:C1335960,
umls-concept:C1366753,
umls-concept:C1548425,
umls-concept:C1710082
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pubmed:issue |
4
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pubmed:dateCreated |
2003-2-18
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pubmed:abstractText |
The aim of this study was to evaluate the participation of the Jak-1 and STAT-1 proteins in sodium butyrate-induced apoptosis in 2C4 cells derived from human fibrosarcoma. Making use of Jak-1 or STAT-1 deficient cell lines, we demonstrated that the apoptotic process induced by butyrate is independent of the presence of these proteins. In addition, this work showed that, although the constitutive expression of pro-caspases-2 and -3 is reduced in STAT-1 cells, the activity of caspase-3 is preserved in both Jak-1 and STAT-1 deficient cells and is similar to that seen in 2C4 parental cells. In conclusion, we demonstrated that the absence of functionally active Jak-1 or STAT-1 protein directly affects the TNF-alpha-induced apoptosis, but does not alter the sodium butyrate-induced apoptosis in cells derived from human fibrosarcoma.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Butyrates,
http://linkedlifedata.com/resource/pubmed/chemical/CASP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/JAK1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
301
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
968-73
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12589807-Apoptosis,
pubmed-meshheading:12589807-Butyrates,
pubmed-meshheading:12589807-Caspase 2,
pubmed-meshheading:12589807-Caspase 3,
pubmed-meshheading:12589807-Caspases,
pubmed-meshheading:12589807-DNA-Binding Proteins,
pubmed-meshheading:12589807-Dose-Response Relationship, Drug,
pubmed-meshheading:12589807-Enzyme Activation,
pubmed-meshheading:12589807-Enzyme Precursors,
pubmed-meshheading:12589807-Fibrosarcoma,
pubmed-meshheading:12589807-Humans,
pubmed-meshheading:12589807-Janus Kinase 1,
pubmed-meshheading:12589807-Protein-Tyrosine Kinases,
pubmed-meshheading:12589807-STAT1 Transcription Factor,
pubmed-meshheading:12589807-Trans-Activators,
pubmed-meshheading:12589807-Tumor Cells, Cultured,
pubmed-meshheading:12589807-Tumor Necrosis Factor-alpha
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pubmed:year |
2003
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pubmed:articleTitle |
Apoptosis induced by butyrate is independent of Jak/STAT signaling in a fibrosarcoma cell line.
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pubmed:affiliation |
Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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