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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-2-18
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pubmed:abstractText |
Rod photoreceptors are susceptible to light-induced cell death. Previous results have suggested that the neurotrophin receptor p75 in Müller cells controls photoreceptor cell death during light-exposure by suppressing trophic factor release; and consequently, if p75 is blocked or eliminated during light-exposure, apoptosis is delayed. We explored this question by examining photoreceptor cell survival in albino p75(-/-) mice as well as their heterozygous and homozygous littermates. Photoreceptor cell death was examined in semi-thin sections by counting the remaining rows of photoreceptors. No difference in the amount of cell death was found between p75(+/+) and p75(-/-) animals, whereas the single copy of p75 in the heterozygous p75(+/-) mice provided significant neuroprotection. Cell death in the wild-type animals may indeed be mediated by p75, whereas other known apoptosis pathways may be activated in the p75(-/-) mice. The pro-apoptotic activity of the p75 receptor may have been partially suppressed in the heterozygous p75(+/-) mice by the silencing effect of the Trk receptor. Thus, our results suggest that p75 signaling does not mediate the main apoptosis pathway activated during light-damage.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-10347198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-10436046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-10449788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-10516311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-10530749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-10627584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-10711715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-10717677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-10839371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-10851172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-11203139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-11311041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-11598917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-11681842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-11747369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-11883606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-11992464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-1312136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-1317267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-1454803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-1527595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-3653273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-9101022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-9454843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-9472042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-9476210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-9501871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12589782-9895316
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0014-4835
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
125-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12589782-Animals,
pubmed-meshheading:12589782-Apoptosis,
pubmed-meshheading:12589782-Light,
pubmed-meshheading:12589782-Mice,
pubmed-meshheading:12589782-Mice, Mutant Strains,
pubmed-meshheading:12589782-Radiation Injuries,
pubmed-meshheading:12589782-Receptor, Nerve Growth Factor,
pubmed-meshheading:12589782-Receptors, Nerve Growth Factor,
pubmed-meshheading:12589782-Retinal Rod Photoreceptor Cells
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pubmed:year |
2003
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pubmed:articleTitle |
Lack of p75 receptor does not protect photoreceptors from light-induced cell death.
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pubmed:publicationType |
Letter,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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