Source:http://linkedlifedata.com/resource/pubmed/id/12586538
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2003-2-14
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| pubmed:abstractText |
There is an increasing interest in the measurement of nitric oxide (NO.) in the airways. NO. is a free radical that reacts rapidly with reactive oxygen species in aqueous solution to form peroxynitrite which can then break down to nitrite (NO(2)(-)) and nitrate (NO(3)(-)). NO(3)(-) is considered a stable oxidative end product of NO. metabolism. The aim of this study was to assay NO(3)(-) in exhaled breath condensate (EBC) of normal nonsmoking and smoking subjects, asthmatics, patients with obstructive pulmonary disease (COPD), and patients with community-acquired pneumonia (CAP). EBC was collected using a glass condenser and samples were assayed for NO(3)(-) by ion chromatography followed by conductivity measurement. NO(3)(-) was detectable in EBC of all subjects. NO(3)(-) was elevated in smokers [median (range)] [62.5 (9.6-158.0) microM] and in asthmatics [68.0 (25.8-194.6) microM] compared to controls [9.6 (2.6-119.4) microM; p=0.003 and p=0.006, respectively], whereas NO(3)(-) was not elevated in COPD patients [24.1 (1.9-337.0 microM]. The concentration of NO(3)(-) in patients with CAP [243.4 (26.1-584.5) microM] was higher than that in controls (p=0.002) and NO(3)(-) values decreased after treatment and recovery from illness [40.0 (4.1-167.0) microM, p=0.009]. This study shows that NO(3)(-) is detectable in EBC of healthy subjects and it varies in patients with inflammatory airway diseases.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
1089-8603
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
8
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
26-30
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12586538-Adult,
pubmed-meshheading:12586538-Asthma,
pubmed-meshheading:12586538-Breath Tests,
pubmed-meshheading:12586538-Case-Control Studies,
pubmed-meshheading:12586538-Female,
pubmed-meshheading:12586538-Humans,
pubmed-meshheading:12586538-Lung Diseases,
pubmed-meshheading:12586538-Male,
pubmed-meshheading:12586538-Middle Aged,
pubmed-meshheading:12586538-Nitrates,
pubmed-meshheading:12586538-Pneumonia,
pubmed-meshheading:12586538-Pulmonary Disease, Chronic Obstructive,
pubmed-meshheading:12586538-Smoking
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| pubmed:year |
2003
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| pubmed:articleTitle |
Nitrate in exhaled breath condensate of patients with different airway diseases.
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| pubmed:affiliation |
Dipartimento di Clinica Medica, Nefrologia e Scienze della Prevenzione, Università degli Studi di Parma, Via Gramsci 14, 43100 Parma, Italy. m.corradi@iol.it
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| pubmed:publicationType |
Journal Article
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