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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-2-14
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pubmed:abstractText |
Recent postmortem studies demonstrate disrupted neurochemistry of the noradrenergic locus coeruleus (LC) in major depression (MD). Increased levels of tyrosine hydroxylase and decreased levels of norepinephrine transporter implicate a norepinephrine deficiency in the LC in MD. Here we describe a study of alpha2-adrenoceptors in the LC and raphe nuclei of subjects with MD compared with psychiatrically normal control subjects.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-3223
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
315-23
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12586450-Adrenergic alpha-2 Receptor Agonists,
pubmed-meshheading:12586450-Adrenergic alpha-Agonists,
pubmed-meshheading:12586450-Adult,
pubmed-meshheading:12586450-Affinity Labels,
pubmed-meshheading:12586450-Aged,
pubmed-meshheading:12586450-Autopsy,
pubmed-meshheading:12586450-Autoradiography,
pubmed-meshheading:12586450-Clonidine,
pubmed-meshheading:12586450-Depressive Disorder, Major,
pubmed-meshheading:12586450-Female,
pubmed-meshheading:12586450-Humans,
pubmed-meshheading:12586450-Locus Coeruleus,
pubmed-meshheading:12586450-Male,
pubmed-meshheading:12586450-Middle Aged,
pubmed-meshheading:12586450-Radiopharmaceuticals,
pubmed-meshheading:12586450-Raphe Nuclei,
pubmed-meshheading:12586450-Receptors, Adrenergic, alpha-2
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pubmed:year |
2003
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pubmed:articleTitle |
Elevated agonist binding to alpha2-adrenoceptors in the locus coeruleus in major depression.
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pubmed:affiliation |
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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