Linked Life Data

12586313

Source:http://linkedlifedata.com/resource/pubmed/id/12586313

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-2-14
pubmed:abstractText
Adrenergic receptors are pharmacologically classified into the receptor types alpha(1), alpha(2), beta(1), beta(2), and beta(3). Structural differences and varying affinities in radioligand binding studies lead to a further classification of alpha(1)- and alpha(2)-receptors into subtypes which are termed alpha(1A) (formerly alpha(1C)), alpha(1B), and alpha(1D) (formerly alpha(1AD)), and alpha(2AD), alpha(2B), and alpha(2C), respectively. mRNA expression of all but one alpha-adrenergic receptor subtypes and of all beta-adrenergic receptor types was measured quantitatively in total RNA extracted from mammary tissue of 10 lactating dairy cows by real-time reverse transcription (RT) polymerase chain reaction (PCR). mRNA expression of alpha(1)-adrenergic receptors was highest for the alpha(1A)-subtype followed by alpha(1B), whereas the alpha(1D)-subtype could not be detected. The highest mRNA expression of alpha(2)-adrenergic receptors was found for the alpha(2AD)-subtype, followed by alpha(2B) and alpha(2C). Within the beta-adrenergic receptors, the beta(2)-receptor type was most highly expressed, followed by beta(1) and beta(3). In conclusion, eight of nine adrenergic receptors classified to date were detected and relatively quantified in the mammary gland of dairy cows.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0739-7240
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
123-35
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12586313-Animals, pubmed-meshheading:12586313-Base Sequence, pubmed-meshheading:12586313-Cattle, pubmed-meshheading:12586313-Female, pubmed-meshheading:12586313-Humans, pubmed-meshheading:12586313-Lactation, pubmed-meshheading:12586313-Mammary Glands, Animal, pubmed-meshheading:12586313-RNA, Messenger, pubmed-meshheading:12586313-Receptors, Adrenergic, alpha, pubmed-meshheading:12586313-Receptors, Adrenergic, alpha-1, pubmed-meshheading:12586313-Receptors, Adrenergic, alpha-2, pubmed-meshheading:12586313-Receptors, Adrenergic, beta, pubmed-meshheading:12586313-Receptors, Adrenergic, beta-1, pubmed-meshheading:12586313-Receptors, Adrenergic, beta-2, pubmed-meshheading:12586313-Receptors, Adrenergic, beta-3, pubmed-meshheading:12586313-Reverse Transcriptase Polymerase Chain Reaction
pubmed:year
2003
pubmed:articleTitle
Detection and quantification of mRNA expression of alpha- and beta-adrenergic receptor subtypes in the mammary gland of dairy cows.
pubmed:affiliation
Institute of Physiology, Technical University Munich, D-85354 Freising-Weihenstephan, Germany.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't