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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2-3
|
| pubmed:dateCreated |
1975-12-4
|
| pubmed:abstractText |
Intraventricular administration of taurine in the rat caused hypothermia, the extent of which was directly dependent upon the thermal gradient between the body and the environment. Pre-treatment of animals with p-chlorophenylalanine, which depleted most of the brain serotonin, strongly reduced the hypothermia induced by taurine. Pre-treatment with alpha-methyltyrosine induced hypothermia and sedation in animals. When this was followed by a taurine injection, they exhibited a decrease in body temperature which fitted the curve relating thermal gradients to hypothermic responses. It is suggested that taurine induced hypothermia in rat is mediated in part by central 5-HT systems.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0028-1298
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
288
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
179-84
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:125856-Animals,
pubmed-meshheading:125856-Brain Chemistry,
pubmed-meshheading:125856-Depression, Chemical,
pubmed-meshheading:125856-Female,
pubmed-meshheading:125856-Fenclonine,
pubmed-meshheading:125856-Hypothermia,
pubmed-meshheading:125856-Methyltyrosines,
pubmed-meshheading:125856-Rats,
pubmed-meshheading:125856-Serotonin,
pubmed-meshheading:125856-Taurine,
pubmed-meshheading:125856-Time Factors
|
| pubmed:year |
1975
|
| pubmed:articleTitle |
Is taurine-induced hypothermia in the rat mediated by 5-HT?
|
| pubmed:publicationType |
Journal Article
|