| pubmed-article:12584411 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12584411 | lifeskim:mentions | umls-concept:C0814999 | lld:lifeskim |
| pubmed-article:12584411 | lifeskim:mentions | umls-concept:C0164209 | lld:lifeskim |
| pubmed-article:12584411 | lifeskim:mentions | umls-concept:C0038585 | lld:lifeskim |
| pubmed-article:12584411 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:12584411 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12584411 | lifeskim:mentions | umls-concept:C2610927 | lld:lifeskim |
| pubmed-article:12584411 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:12584411 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12584411 | lifeskim:mentions | umls-concept:C2347946 | lld:lifeskim |
| pubmed-article:12584411 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12584411 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12584411 | pubmed:dateCreated | 2003-2-13 | lld:pubmed |
| pubmed-article:12584411 | pubmed:abstractText | Herein, we provide evidence of the expression and function of substance P (SP) and neurokinin-1 receptor (NK-1R) in the rat thymus. In situ hybridization evidenced NK-1R mRNA mainly in the thymic medulla, and Northern blot analysis of mRNA from FACS-sorted thymocytes identified NK-1R on CD4+, CD8+ and double-positive subpopulations. With flow cytometry, it could be seen that NK-1R was expressed on the majority of CD5+ thymocytes, and it was identified by Western blot analysis as two bands migrating at 44 and 54 kD. SP administration rescues thymocytes from spontaneous and NK-1R antagonist (SR140333)-induced apoptosis and stimulates concanavalin A (ConA)-induced thymocyte proliferation, CD25 expression and IL-2 production, whereas SR140333 exerts inhibitory effects on these functions. We also demonstrated the expression of mRNA for the SP precursor preprotachykinin-A in the thymic medulla and purified CD5+ thymocytes. SP protein was detected on 40% of CD5+ thymocytes and identified as a band of 1.3 kD by Western blot analysis. Finally, thymocytes spontaneously released SP, which was increased upon ConA or CD3 stimulation. | lld:pubmed |
| pubmed-article:12584411 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12584411 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12584411 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12584411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12584411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12584411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12584411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12584411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12584411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12584411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12584411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12584411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12584411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12584411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12584411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12584411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12584411 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12584411 | pubmed:issn | 1021-7401 | lld:pubmed |
| pubmed-article:12584411 | pubmed:author | pubmed-author:PerfumiMarina... | lld:pubmed |
| pubmed-article:12584411 | pubmed:author | pubmed-author:PiccoliMarioM | lld:pubmed |
| pubmed-article:12584411 | pubmed:author | pubmed-author:SantoniGiorgi... | lld:pubmed |
| pubmed-article:12584411 | pubmed:author | pubmed-author:LucciariniRob... | lld:pubmed |
| pubmed-article:12584411 | pubmed:author | pubmed-author:AmantiniConsu... | lld:pubmed |
| pubmed-article:12584411 | pubmed:author | pubmed-author:MorroneStefan... | lld:pubmed |
| pubmed-article:12584411 | pubmed:author | pubmed-author:PompeiPierlui... | lld:pubmed |
| pubmed-article:12584411 | pubmed:author | pubmed-author:NabissiMassim... | lld:pubmed |
| pubmed-article:12584411 | pubmed:copyrightInfo | Copyright 2003 S. Karger AG, Basel | lld:pubmed |
| pubmed-article:12584411 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12584411 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:12584411 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12584411 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12584411 | pubmed:pagination | 232-46 | lld:pubmed |
| pubmed-article:12584411 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12584411 | pubmed:articleTitle | Expression of substance P and its neurokinin-1 receptor on thymocytes: functional relevance in the regulation of thymocyte apoptosis and proliferation. | lld:pubmed |
| pubmed-article:12584411 | pubmed:affiliation | Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Camerino, Italy. giorgio.santoni@unicam.it | lld:pubmed |
| pubmed-article:12584411 | pubmed:publicationType | Journal Article | lld:pubmed |
