| pubmed-article:12584325 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12584325 | lifeskim:mentions | umls-concept:C0037224 | lld:lifeskim |
| pubmed-article:12584325 | lifeskim:mentions | umls-concept:C0026447 | lld:lifeskim |
| pubmed-article:12584325 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:12584325 | lifeskim:mentions | umls-concept:C0205177 | lld:lifeskim |
| pubmed-article:12584325 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:12584325 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:12584325 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:12584325 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:12584325 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:12584325 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:12584325 | pubmed:dateCreated | 2003-2-13 | lld:pubmed |
| pubmed-article:12584325 | pubmed:abstractText | Adaptive immune responses of gammadelta T cells during active mycobacterial coinfection of human immunodeficiency virus-infected humans have not been studied. Macaques infected with the simian immunodeficiency virus (SIV) SIVmac were employed to determine the extent to which a coincident AIDS virus infection might compromise immune responses of mycobacterium-specific Vgamma2Vdelta2(+) T cells during active mycobacterial infection. Control SIVmac-negative macaques developed primary and recall expansions of phosphoantigen-specific Vgamma2Vdelta2(+) T cells after Mycobacterium bovis BCG infection and BCG reinfection, respectively. In contrast, SIVmac-infected macaques did not exhibit sound primary and recall expansions of Vgamma2Vdelta2(+) T cells in the blood and pulmonary alveoli following BCG infection and reinfection. The absence of adaptive Vgamma2Vdelta2(+) T-cell responses was associated with profound CD4(+) T-cell deficiency and subsequent development of SIVmac-related tuberculosis-like disease in the coinfected monkeys. Consistently, Vgamma2Vdelta2(+) T cells from coinfected monkeys displayed a reduced capacity to expand in vitro following stimulation with phosphoantigen. The reduced ability of Vgamma2Vdelta2(+) peripheral blood lymphocytes (PBL) to expand could be restored to some extent by coculture of these cells with CD4(+) T cells purified from PBL of SIV-negative monkeys. Furthermore, naïve monkeys inoculated simultaneously with SIVmac and BCG were unable to sustain expansion of Vgamma2Vdelta2(+) T cells at the time that the coinfected monkeys developed lymphoid depletion and a fatal tuberculosis-like disease. Nevertheless, no deletion in Vdelta2 T-cell receptor repertoire was identified in SIVmac-BCG-coinfected macaques, implicating an SIVmac-induced down-regulation rather than a clonal exhaustion of these cells. Thus, an SIVmac-induced compromise of the adaptive Vgamma2Vdelta2(+) T-cell responses may contribute to the immunopathogenesis of the SIV-related tuberculosis-like disease in macaques. | lld:pubmed |
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| pubmed-article:12584325 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12584325 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12584325 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12584325 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12584325 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12584325 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:12584325 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:12584325 | pubmed:author | pubmed-author:LetvinNorman... | lld:pubmed |
| pubmed-article:12584325 | pubmed:author | pubmed-author:ShenYunY | lld:pubmed |
| pubmed-article:12584325 | pubmed:author | pubmed-author:ZhouDejiangD | lld:pubmed |
| pubmed-article:12584325 | pubmed:author | pubmed-author:ShenLingL | lld:pubmed |
| pubmed-article:12584325 | pubmed:author | pubmed-author:SimonMeredith... | lld:pubmed |
| pubmed-article:12584325 | pubmed:author | pubmed-author:SehgalPrabhat... | lld:pubmed |
| pubmed-article:12584325 | pubmed:author | pubmed-author:ChenZheng WZW | lld:pubmed |
| pubmed-article:12584325 | pubmed:author | pubmed-author:QiuLiyouL | lld:pubmed |
| pubmed-article:12584325 | pubmed:author | pubmed-author:WangQifanQ | lld:pubmed |
| pubmed-article:12584325 | pubmed:author | pubmed-author:HuangDanD | lld:pubmed |
| pubmed-article:12584325 | pubmed:author | pubmed-author:LaiXiaominX | lld:pubmed |
| pubmed-article:12584325 | pubmed:author | pubmed-author:DuGeorge ZGZ | lld:pubmed |
| pubmed-article:12584325 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12584325 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:12584325 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12584325 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12584325 | pubmed:pagination | 2998-3006 | lld:pubmed |
| pubmed-article:12584325 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:12584325 | pubmed:meshHeading | pubmed-meshheading:12584325... | lld:pubmed |
| pubmed-article:12584325 | pubmed:meshHeading | pubmed-meshheading:12584325... | lld:pubmed |
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| pubmed-article:12584325 | pubmed:meshHeading | pubmed-meshheading:12584325... | lld:pubmed |
| pubmed-article:12584325 | pubmed:meshHeading | pubmed-meshheading:12584325... | lld:pubmed |
| pubmed-article:12584325 | pubmed:meshHeading | pubmed-meshheading:12584325... | lld:pubmed |
| pubmed-article:12584325 | pubmed:meshHeading | pubmed-meshheading:12584325... | lld:pubmed |
| pubmed-article:12584325 | pubmed:meshHeading | pubmed-meshheading:12584325... | lld:pubmed |
| pubmed-article:12584325 | pubmed:meshHeading | pubmed-meshheading:12584325... | lld:pubmed |
| pubmed-article:12584325 | pubmed:meshHeading | pubmed-meshheading:12584325... | lld:pubmed |
| pubmed-article:12584325 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12584325 | pubmed:articleTitle | Inhibition of adaptive Vgamma2Vdelta2+ T-cell responses during active mycobacterial coinfection of simian immunodeficiency virus SIVmac-infected monkeys. | lld:pubmed |
| pubmed-article:12584325 | pubmed:affiliation | Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. | lld:pubmed |
| pubmed-article:12584325 | pubmed:publicationType | Journal Article | lld:pubmed |
