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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2003-2-13
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pubmed:abstractText |
Adaptive immune responses of gammadelta T cells during active mycobacterial coinfection of human immunodeficiency virus-infected humans have not been studied. Macaques infected with the simian immunodeficiency virus (SIV) SIVmac were employed to determine the extent to which a coincident AIDS virus infection might compromise immune responses of mycobacterium-specific Vgamma2Vdelta2(+) T cells during active mycobacterial infection. Control SIVmac-negative macaques developed primary and recall expansions of phosphoantigen-specific Vgamma2Vdelta2(+) T cells after Mycobacterium bovis BCG infection and BCG reinfection, respectively. In contrast, SIVmac-infected macaques did not exhibit sound primary and recall expansions of Vgamma2Vdelta2(+) T cells in the blood and pulmonary alveoli following BCG infection and reinfection. The absence of adaptive Vgamma2Vdelta2(+) T-cell responses was associated with profound CD4(+) T-cell deficiency and subsequent development of SIVmac-related tuberculosis-like disease in the coinfected monkeys. Consistently, Vgamma2Vdelta2(+) T cells from coinfected monkeys displayed a reduced capacity to expand in vitro following stimulation with phosphoantigen. The reduced ability of Vgamma2Vdelta2(+) peripheral blood lymphocytes (PBL) to expand could be restored to some extent by coculture of these cells with CD4(+) T cells purified from PBL of SIV-negative monkeys. Furthermore, naïve monkeys inoculated simultaneously with SIVmac and BCG were unable to sustain expansion of Vgamma2Vdelta2(+) T cells at the time that the coinfected monkeys developed lymphoid depletion and a fatal tuberculosis-like disease. Nevertheless, no deletion in Vdelta2 T-cell receptor repertoire was identified in SIVmac-BCG-coinfected macaques, implicating an SIVmac-induced down-regulation rather than a clonal exhaustion of these cells. Thus, an SIVmac-induced compromise of the adaptive Vgamma2Vdelta2(+) T-cell responses may contribute to the immunopathogenesis of the SIV-related tuberculosis-like disease in macaques.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12584325-10068336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12584325-10390546,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/12584325-9973496
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-538X
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pubmed:author |
pubmed-author:ChenZheng WZW,
pubmed-author:DuGeorge ZGZ,
pubmed-author:HuangDanD,
pubmed-author:LaiXiaominX,
pubmed-author:LetvinNorman LNL,
pubmed-author:QiuLiyouL,
pubmed-author:SehgalPrabhatP,
pubmed-author:ShenLingL,
pubmed-author:ShenYunY,
pubmed-author:SimonMeredithM,
pubmed-author:WangQifanQ,
pubmed-author:ZhouDejiangD
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pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2998-3006
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12584325-AIDS-Related Opportunistic Infections,
pubmed-meshheading:12584325-Animals,
pubmed-meshheading:12584325-Humans,
pubmed-meshheading:12584325-Lymphocyte Activation,
pubmed-meshheading:12584325-Macaca,
pubmed-meshheading:12584325-Mycobacterium bovis,
pubmed-meshheading:12584325-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:12584325-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:12584325-Simian immunodeficiency virus,
pubmed-meshheading:12584325-T-Lymphocytes,
pubmed-meshheading:12584325-Tuberculosis
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pubmed:year |
2003
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pubmed:articleTitle |
Inhibition of adaptive Vgamma2Vdelta2+ T-cell responses during active mycobacterial coinfection of simian immunodeficiency virus SIVmac-infected monkeys.
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pubmed:affiliation |
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
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pubmed:publicationType |
Journal Article
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