Growing evidence demonstrates that local well-ordered structures are closely correlated with cis-acting elements in the post-transcriptional regulation of gene expression. The prediction of a well-ordered folding sequence (WFS) in genomic sequences is very helpful in the determination of local RNA elements with structure-dependent functions in mRNAs.
Laboratory of Experimental and Computational Biology, NCI Center for Cancer Research, National Cancer Institute, NIH, Bldg 469, Room 151, Frederick, MD 21702, USA. shuyun@orleans.ncifcrf.gov
