Linked Life Data

12581658

Source:http://linkedlifedata.com/resource/pubmed/id/12581658

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-2-12
pubmed:abstractText
It is characteristic of eukaryotic transcription that a unique combination of multiple transcriptional regulatory proteins bound to promoter DNA specifically activate or repress downstream target genes; this is referred to as combinatorial gene regulation. Recently determined structures have revealed different modes of protein-protein interaction on the promoter DNA from near (e.g. the Runx1-CBFbeta-DNA, NFAT-Fos-Jun-DNA, GABPalpha-GABPbeta-DNA, Ets-1-Pax-5-DNA and PU.1-IRF-4-DNA complexes) and afar with DNA looping (e.g. the c-Myb-C/EBPbeta-DNA complex), and their regulatory mechanisms.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0959-440X
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
40-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:12581658-Binding Sites, pubmed-meshheading:12581658-CCAAT-Enhancer-Binding Proteins, pubmed-meshheading:12581658-Core Binding Factor Alpha 2 Subunit, pubmed-meshheading:12581658-DNA, pubmed-meshheading:12581658-DNA-Binding Proteins, pubmed-meshheading:12581658-Eukaryotic Cells, pubmed-meshheading:12581658-Gene Expression Regulation, pubmed-meshheading:12581658-Genes, Regulator, pubmed-meshheading:12581658-Macromolecular Substances, pubmed-meshheading:12581658-Models, Molecular, pubmed-meshheading:12581658-Nucleic Acid Conformation, pubmed-meshheading:12581658-Promoter Regions, Genetic, pubmed-meshheading:12581658-Protein Binding, pubmed-meshheading:12581658-Protein Conformation, pubmed-meshheading:12581658-Protein Structure, Tertiary, pubmed-meshheading:12581658-Proto-Oncogene Proteins, pubmed-meshheading:12581658-Proto-Oncogene Proteins c-myb, pubmed-meshheading:12581658-Transcription, Genetic, pubmed-meshheading:12581658-Transcription Factor AP-2, pubmed-meshheading:12581658-Transcription Factor CHOP, pubmed-meshheading:12581658-Transcription Factors
pubmed:year
2003
pubmed:articleTitle
Eukaryotic transcriptional regulatory complexes: cooperativity from near and afar.
pubmed:affiliation
Department of Biochemistry, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. ogata@med.yokohama-cu.ac.jp
pubmed:publicationType
Journal Article, Review