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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2003-2-12
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pubmed:abstractText |
Sparassis crispa Fr. in an edible mushroom recently cultivable in Japan. A branched beta-glucan from S. crispa (SCG) is a major 6-branched 1,3-beta-D-glucan showing antitumor activity. In this study, we examined interferon-gamma (IFN-gamma) induction by SCG from splenocytes in DBA/2 mice in vitro. In the splenocytes derived from almost all inbred strains of mice except for DBA/1 and DBA/2 mice, IFN-gamma production was not induced by SCG. The breeder and genders of DBA/2 mice showed no influence on IFN-gamma induction by SCG. On the other hand, the magnitude of IFN-gamma induction was lower in young mice than in their older counterparts. IFN-gamma was induced by SCG in adherent splenocytes, but IFN-gamma production was most significantly increased by SCG in instances involving coexistence of adherent and nonadherent splenocytes. In fact, inhibition of cell-cell contact reduced IFN-gamma induction by SCG. In addition, interleukin-12 p70 (IL-12p70) was induced by SCG in DBA/2 mice. It was suggested that soluble factors and cell-cell contact mediate synergistic effects on SCG-induced IFN-gamma production.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1079-9907
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1227-39
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12581496-Agaricales,
pubmed-meshheading:12581496-Animals,
pubmed-meshheading:12581496-Antineoplastic Agents,
pubmed-meshheading:12581496-Cells, Cultured,
pubmed-meshheading:12581496-Glucans,
pubmed-meshheading:12581496-Interferon-gamma,
pubmed-meshheading:12581496-Interleukins,
pubmed-meshheading:12581496-Japan,
pubmed-meshheading:12581496-Lipopolysaccharides,
pubmed-meshheading:12581496-Lymphocytes,
pubmed-meshheading:12581496-Macrophages,
pubmed-meshheading:12581496-Mice,
pubmed-meshheading:12581496-Mice, Inbred BALB C,
pubmed-meshheading:12581496-Mice, Inbred C3H,
pubmed-meshheading:12581496-Mice, Inbred C57BL,
pubmed-meshheading:12581496-Mice, Inbred CBA,
pubmed-meshheading:12581496-Mice, Inbred DBA,
pubmed-meshheading:12581496-Mice, Inbred Strains,
pubmed-meshheading:12581496-Phytotherapy,
pubmed-meshheading:12581496-Plant Extracts,
pubmed-meshheading:12581496-beta-Glucans
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pubmed:year |
2002
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pubmed:articleTitle |
IFN-gamma induction by SCG, 1,3-beta-D-glucan from Sparassis crispa, in DBA/2 mice in vitro.
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pubmed:affiliation |
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
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pubmed:publicationType |
Journal Article
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