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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-2-12
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pubmed:abstractText |
Neointima formation is a characteristic feature of atherosclerosis and post-angioplasty restenosis, in which various soluble factors and mechanical injury stimulate signalling pathways in vascular smooth muscle cells (VSMC), promoting their migration and proliferation, and the eventual formation of the neointima. The transcription factor NF-kappaB has been shown to play a pivotal role in this process. Hexamethylene bisacetamide, an inhibitor of VSMC proliferation, induces the mRNA expression of HEXIM1 (hexamethylene bisacetamide-inducible protein 1). However, the protein expression and function of HEXIM1 remain unknown.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1356-9597
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
95-107
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12581153-Acetamides,
pubmed-meshheading:12581153-Amino Acid Sequence,
pubmed-meshheading:12581153-Animals,
pubmed-meshheading:12581153-COS Cells,
pubmed-meshheading:12581153-Cell Nucleus,
pubmed-meshheading:12581153-Cercopithecus aethiops,
pubmed-meshheading:12581153-Cytoplasm,
pubmed-meshheading:12581153-Gene Expression Regulation,
pubmed-meshheading:12581153-Genes, Reporter,
pubmed-meshheading:12581153-Glutathione Transferase,
pubmed-meshheading:12581153-HeLa Cells,
pubmed-meshheading:12581153-Humans,
pubmed-meshheading:12581153-Molecular Sequence Data,
pubmed-meshheading:12581153-Muscle, Smooth, Vascular,
pubmed-meshheading:12581153-NF-kappa B,
pubmed-meshheading:12581153-RNA, Messenger,
pubmed-meshheading:12581153-RNA-Binding Proteins,
pubmed-meshheading:12581153-Recombinant Fusion Proteins,
pubmed-meshheading:12581153-Repressor Proteins
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pubmed:year |
2003
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pubmed:articleTitle |
Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells.
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pubmed:affiliation |
Division of Clinical Immunology, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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