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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-2-12
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pubmed:abstractText |
Molecular and cytogenetic studies performed in 305 adult acute lymphoblastic leukaemia (ALL) patients enrolled in the gimema (Gruppo Italiano Malattie EMatologiche dell'Adulto) multicentric protocols identified an E2A-PBX1 fusion and/or t(1;19) in 10 patients (3.3%). All had common ALL, were mostly CyIg+ and were CD34/CD13/CD33-. Nine patients achieved a complete remission (CR); five patients showed a haematological relapse after 7 months (median). Four patients are alive in first CR with a median follow-up of 29 months; three patients are molecularly negative. This abnormality is frequently associated with early treatment failure. E2A-PBX1+ adult ALL should be considered for intensified treatment strategies and monitoring of minimal residual disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0007-1048
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pubmed:author |
pubmed-author:AnninoLucianaL,
pubmed-author:CuneoAntonioA,
pubmed-author:DamasioEugenioE,
pubmed-author:Di RaimondoFrancescoF,
pubmed-author:EliaLoredanaL,
pubmed-author:FaziPaolaP,
pubmed-author:FoaRobinR,
pubmed-author:HungerStephen PSP,
pubmed-author:LombardoRominaR,
pubmed-author:ManciniMarcoM,
pubmed-author:MandelliFrancoF,
pubmed-author:MecucciCristinaC,
pubmed-author:MorraEnricaE,
pubmed-author:RecchiaAnnaA,
pubmed-author:SaglioGiuseppeG,
pubmed-author:SpecchiaGiorginaG,
pubmed-author:TafuriAgostinoA,
pubmed-author:TorelliGiuseppeG,
pubmed-author:VitaleAntonellaA,
pubmed-author:VolpeEttoreE
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pubmed:issnType |
Print
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pubmed:volume |
120
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
484-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12580965-Adolescent,
pubmed-meshheading:12580965-Adult,
pubmed-meshheading:12580965-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:12580965-Chromosomes, Human, Pair 1,
pubmed-meshheading:12580965-Chromosomes, Human, Pair 19,
pubmed-meshheading:12580965-Female,
pubmed-meshheading:12580965-Follow-Up Studies,
pubmed-meshheading:12580965-Homeodomain Proteins,
pubmed-meshheading:12580965-Humans,
pubmed-meshheading:12580965-Karyotyping,
pubmed-meshheading:12580965-Male,
pubmed-meshheading:12580965-Middle Aged,
pubmed-meshheading:12580965-Oncogene Proteins, Fusion,
pubmed-meshheading:12580965-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:12580965-Prognosis,
pubmed-meshheading:12580965-Recurrence,
pubmed-meshheading:12580965-Translocation, Genetic,
pubmed-meshheading:12580965-Treatment Failure
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pubmed:year |
2003
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pubmed:articleTitle |
E2A-PBX1 fusion in adult acute lymphoblastic leukaemia: biological and clinical features.
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pubmed:affiliation |
Dipartimento di Biotecnologie Cellulari ed Ematologia, University La Sapienza, Rome, Italy. rfoa@bce.uniroma1.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
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