Source:http://linkedlifedata.com/resource/pubmed/id/12579400
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2003-2-11
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pubmed:abstractText |
Autosomal recessive polycystic kidney disease (ARPKD) is a relatively common form of pediatric polycystic kidney disease with an incidence of 1:20,000 live births. Previous reports, primarily from populations of European origin, indicate that the clinical presentation and disease course are quite variable. Using a retrospective study design, we sought to determine whether the clinical course and outcome of our multi-ethnic patient cohort differs from the published literature. A 10-year (1990-2000) retrospective study was conducted in which we reviewed the clinical, histopathological, and imaging records of our 31 ARPKD patients. Patients were diagnosed between 0 and 14 years of age, with 17 (55%) presenting within the 1st month of life. The mean follow-up was 67 months and age at last follow-up ranged from 0.5 to 16 years. Of the 17 patients diagnosed as neonates, 11 (65%) had respiratory insufficiency complicated by pneumothoraces. Two died shortly after birth and 2 died within the 1st year of life due to respiratory failure. Among the 13 neonatal survivors, 7 (54%) developed progressive renal insufficiency, whereas 6 of 14 (43%) of those children who presented beyond 1 month of age developed renal insufficiency. Hypertension was present in 55% of our patients, with nearly all neonatal survivors requiring antihypertensive management. Evidence of portal hypertension was found in 10 (37%) of the 27 patients who survived the 1st year of life. In our multi-ethnic ARPKD cohort, the 1-year survival rate (87%) and the clinical variability are comparable to those previously reported. With the recent identification of the PKHD1 gene, characterization of disease-causing mutations should provide new insights into the molecular basis for this phenotypic variability.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0931-041X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
119-26
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:12579400-Adolescent,
pubmed-meshheading:12579400-Child,
pubmed-meshheading:12579400-Child, Preschool,
pubmed-meshheading:12579400-Female,
pubmed-meshheading:12579400-Humans,
pubmed-meshheading:12579400-Hypertension,
pubmed-meshheading:12579400-Hypertension, Portal,
pubmed-meshheading:12579400-Infant,
pubmed-meshheading:12579400-Infant, Newborn,
pubmed-meshheading:12579400-Kidney Failure, Chronic,
pubmed-meshheading:12579400-Male,
pubmed-meshheading:12579400-Polycystic Kidney, Autosomal Recessive,
pubmed-meshheading:12579400-Retrospective Studies
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pubmed:year |
2003
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pubmed:articleTitle |
Autosomal recessive polycystic kidney disease: outcomes from a single-center experience.
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pubmed:affiliation |
Division of Nephrology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario M5G1X8, Canada.
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pubmed:publicationType |
Journal Article
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