Linked Life Data

12579336

Source:http://linkedlifedata.com/resource/pubmed/id/12579336

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-2-11
pubmed:abstractText
A major obstacle in the treatment of esophageal carcinoma is the intrinsic/acquired resistance to cisplatin-based chemotherapy. Copper-transporting P-type adenosine triphosphatase (ATP7B) has been reported to be associated with cisplatin resistance in vitro. However, the clinical significance of this transporter has not previously been addressed. Our goal was to investigate if ATP7B is expressed in esophageal carcinoma and whether its expression correlates with reduced responsiveness to cisplatin treatment. We retrospectively examined the expression of ATP7B in primary esophageal carcinoma and its association with chemotherapeutic effect. Tissues were surgically removed from 17 esophageal carcinoma patients. Twelve of them received cisplatin-based chemotherapy before surgery. We performed immunohistochemical analysis of ATP7B using a monoclonal antibody against ATP7B in 17 esophageal carcinomas. A variable degree of cytoplasmic staining of tumor cells was observed in 76.5% (13/17 cases) of the analyzed carcinomas. ATP7B expression was not observed in adjacent non-neoplastic tissues. ATP7B positivity was not significant in gender, age, histopathological grading or TNM categories. Patients with ATP7B-positive tumors tended to have an inferior response to chemotherapy compared with the patients with ATP7B-negative tumors. These findings suggest that overexpression of ATP7B in esophageal carcinoma could be associated with unfavorable clinical outcome in patients treated with cisplatin-based chemotherapy. Therefore, ATP7B gene expression might be considered as a chemoresistance marker for cisplatin in the patients of esophageal carcinoma and provider of important information on the strategy against esophageal carcinoma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1107-3756
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
337-41
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12579336-Adenosine Triphosphatases, pubmed-meshheading:12579336-Aged, pubmed-meshheading:12579336-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:12579336-Carcinoma, pubmed-meshheading:12579336-Cation Transport Proteins, pubmed-meshheading:12579336-Cisplatin, pubmed-meshheading:12579336-Copper, pubmed-meshheading:12579336-Esophageal Neoplasms, pubmed-meshheading:12579336-Female, pubmed-meshheading:12579336-Fluorouracil, pubmed-meshheading:12579336-Gene Expression, pubmed-meshheading:12579336-Humans, pubmed-meshheading:12579336-Immunohistochemistry, pubmed-meshheading:12579336-Male, pubmed-meshheading:12579336-Middle Aged, pubmed-meshheading:12579336-Prognosis, pubmed-meshheading:12579336-Retrospective Studies, pubmed-meshheading:12579336-Treatment Outcome
pubmed:year
2003
pubmed:articleTitle
Expression of copper-transporting P-type adenosine triphosphatase in human esophageal carcinoma.
pubmed:affiliation
Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8570, Japan.
pubmed:publicationType
Journal Article, Comparative Study