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rdf:type |
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lifeskim:mentions |
umls-concept:C0006142,
umls-concept:C0033325,
umls-concept:C0040649,
umls-concept:C0040661,
umls-concept:C0279781,
umls-concept:C0332281,
umls-concept:C0475264,
umls-concept:C0521447,
umls-concept:C1367307,
umls-concept:C1449575,
umls-concept:C1519522,
umls-concept:C1710082
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pubmed:issue |
2
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pubmed:dateCreated |
2003-2-10
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pubmed:abstractText |
Although a high frequency of tumors contain constitutively activated signal transducers and activators of transcription 3 (Stat3), its relationship to breast cancer and patient survival has not been determined in a large retrospective study of node-negative tumors. To further elucidate the role of Stat3 in breast cancers, the expression patterns of Stat3 and Phospho-tyrosine residue 705 (Tyr705) Stat3 were correlated with survival outcome and clinicopathological parameters in a large cohort of node-negative breast cancer tumors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
594-600
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12576423-Acute-Phase Proteins,
pubmed-meshheading:12576423-Biological Markers,
pubmed-meshheading:12576423-Breast Neoplasms,
pubmed-meshheading:12576423-Cell Nucleus,
pubmed-meshheading:12576423-DNA-Binding Proteins,
pubmed-meshheading:12576423-Female,
pubmed-meshheading:12576423-Humans,
pubmed-meshheading:12576423-Immunohistochemistry,
pubmed-meshheading:12576423-Lymphatic Metastasis,
pubmed-meshheading:12576423-Multivariate Analysis,
pubmed-meshheading:12576423-Phosphorylation,
pubmed-meshheading:12576423-Phosphotyrosine,
pubmed-meshheading:12576423-Prognosis,
pubmed-meshheading:12576423-Proportional Hazards Models,
pubmed-meshheading:12576423-STAT3 Transcription Factor,
pubmed-meshheading:12576423-Survival Analysis,
pubmed-meshheading:12576423-Time Factors,
pubmed-meshheading:12576423-Trans-Activators
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pubmed:year |
2003
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pubmed:articleTitle |
Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis.
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pubmed:affiliation |
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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