Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-2-10
pubmed:abstractText
TNF-related apoptosis-inducing ligand (TRAIL), a type II membrane protein belonging to the TNF family, induces apoptotic cell death in various types of tumor cells. However, little is known about its pathological and physiological functions in the immune system. In this study, we showed that administration of neutralizing anti-TRAIL mAb markedly increased serum auto-Ab levels, particularly of IgG1 subclass, in autoimmune-prone C3H/HeJ gld/gld mice without affecting lymphocytosis and lymphocytes populations. In an experimental system where TNP-specific Ab production was induced by immunization with TNP-modified syngeneic B lymphoma cells, expression of TRAIL on these cells significantly reduced TNP-specific Ab production, especially of IgG1 subclass, without affecting T cell priming. These results suggest a new role for TRAIL in the suppression of Ab production.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8, http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies, http://linkedlifedata.com/resource/pubmed/chemical/Fas Ligand Protein, http://linkedlifedata.com/resource/pubmed/chemical/Fasl protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Picrates, http://linkedlifedata.com/resource/pubmed/chemical/TNF-Related Apoptosis-Inducing..., http://linkedlifedata.com/resource/pubmed/chemical/Tnfsf10 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha, http://linkedlifedata.com/resource/pubmed/chemical/picric acid
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0008-8749
pubmed:author
pubmed:issnType
Print
pubmed:volume
219
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
82-91
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12576026-Animals, pubmed-meshheading:12576026-Antibodies, pubmed-meshheading:12576026-Antibodies, Monoclonal, pubmed-meshheading:12576026-Antigens, CD4, pubmed-meshheading:12576026-Antigens, CD8, pubmed-meshheading:12576026-Apoptosis, pubmed-meshheading:12576026-Apoptosis Regulatory Proteins, pubmed-meshheading:12576026-Autoantibodies, pubmed-meshheading:12576026-Autoimmune Diseases, pubmed-meshheading:12576026-Fas Ligand Protein, pubmed-meshheading:12576026-Female, pubmed-meshheading:12576026-Immunoglobulin G, pubmed-meshheading:12576026-Injections, Intraperitoneal, pubmed-meshheading:12576026-Lymphoma, B-Cell, pubmed-meshheading:12576026-Membrane Glycoproteins, pubmed-meshheading:12576026-Mice, pubmed-meshheading:12576026-Mice, Inbred BALB C, pubmed-meshheading:12576026-Mice, Inbred C3H, pubmed-meshheading:12576026-Mice, Mutant Strains, pubmed-meshheading:12576026-Mutation, pubmed-meshheading:12576026-Picrates, pubmed-meshheading:12576026-T-Lymphocytes, pubmed-meshheading:12576026-TNF-Related Apoptosis-Inducing Ligand, pubmed-meshheading:12576026-Transfection, pubmed-meshheading:12576026-Tumor Necrosis Factor-alpha
pubmed:year
2002
pubmed:articleTitle
Suppression of antibody production by TNF-related apoptosis-inducing ligand (TRAIL).
pubmed:affiliation
Department of Immunology, Juntendo University School of Medicine, Tokyo 113-8421, Japan. kayagaki@gene.com
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't