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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-2-10
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pubmed:abstractText |
Subthreshold-activating somatodendritic A-type potassium channels have fundamental roles in neuronal signaling and plasticity which depend on their unique cellular localization, voltage dependence, and kinetic properties. Some of the components of A-type K(+) channels have been identified; however, these do not reproduce the properties of the native channels, indicating that key molecular factors have yet to be unveiled. We purified A-type K(+) channel complexes from rat brain membranes and found that DPPX, a protein of unknown function that is structurally related to the dipeptidyl aminopeptidase and cell adhesion protein CD26, is a novel component of A-type K(+) channels. DPPX associates with the channels' pore-forming subunits, facilitates their trafficking and membrane targeting, reconstitutes the properties of the native channels in heterologous expression systems, and is coexpressed with the pore-forming subunits in the somatodendritic compartment of CNS neurons.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0896-6273
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pubmed:author |
pubmed-author:AmarilloYimyY,
pubmed-author:GoldbergEthan MEM,
pubmed-author:IkeharaYukioY,
pubmed-author:MaYuliangY,
pubmed-author:MisumiYoshioY,
pubmed-author:MoWenjunW,
pubmed-author:NadalMarcela SMS,
pubmed-author:NeubertThomas ATA,
pubmed-author:OzaitaAndrésA,
pubmed-author:RudyBernardoB,
pubmed-author:Vega-Saenz de MieraEleazarE
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
449-61
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12575952-Amino Acid Sequence,
pubmed-meshheading:12575952-Animals,
pubmed-meshheading:12575952-Cell Adhesion,
pubmed-meshheading:12575952-Cerebellum,
pubmed-meshheading:12575952-Dendrites,
pubmed-meshheading:12575952-Dipeptidyl Peptidase 4,
pubmed-meshheading:12575952-Extracellular Matrix,
pubmed-meshheading:12575952-Membrane Proteins,
pubmed-meshheading:12575952-Molecular Sequence Data,
pubmed-meshheading:12575952-Nerve Tissue Proteins,
pubmed-meshheading:12575952-Neurons,
pubmed-meshheading:12575952-Oocytes,
pubmed-meshheading:12575952-Potassium Channels,
pubmed-meshheading:12575952-Potassium Channels, Voltage-Gated,
pubmed-meshheading:12575952-Precipitin Tests,
pubmed-meshheading:12575952-Protein Transport,
pubmed-meshheading:12575952-Rats,
pubmed-meshheading:12575952-Rats, Sprague-Dawley,
pubmed-meshheading:12575952-Shal Potassium Channels,
pubmed-meshheading:12575952-Xenopus
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pubmed:year |
2003
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pubmed:articleTitle |
The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels.
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pubmed:affiliation |
Department of Physiology and Neuroscience and Department of Biochemistry, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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