Linked Life Data

12575821

Source:http://linkedlifedata.com/resource/pubmed/id/12575821

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2003-2-10
pubmed:abstractText
Intracellular Ca2+ is regulated within three major compartments: the cytosol, the endoplasmic reticulum and mitochondria. This Chapter reviews the mechanisms involved in handling of Ca2+ within these compartments with reference to potential strategies for neuroprotection. In the cytosol, Ca2+ buffering has a major influence on Ca2+ signals. Cytosolic Ca(2+)-binding proteins such as CB28 participate in Ca2+ buffering and may have a role in resistance to neurotoxicity. In the endoplasmic reticulum, a number of proteins are involved in Ca2+ uptake, lumenal buffering or release, and these may be of value as potential targets for therapeutic intervention. Mitochondria are receiving increasing attention for their role in Ca2+ storage and signaling, and as key players in the processes leading to cell death following Ca2+ overload. An improved understanding of how Ca2+ is controlled within these intracellular compartments, and how these compartments interact, will be important for neuroprotective strategies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-2598
pubmed:author
pubmed:issnType
Print
pubmed:volume
513
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
183-96
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Intracellular Ca2+ handling.
pubmed:affiliation
Department of Physiology, University of Otago, PO Box 913, Dunedin, New Zealand.
pubmed:publicationType
Journal Article, Review