Linked Life Data

12575487

Source:http://linkedlifedata.com/resource/pubmed/id/12575487

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2003-2-10
pubmed:abstractText
Synaptic neural (and neural system) functions are peculiarly sensitive to neuroactive compounds. Pharmacological interference/modulation is readily reflected by modifications in the organization of central nervous system (CNS), electrophysiologic signals occurring spontaneously in response to sensory stimulation (stimulus-related or evoked responses) or elicited in conjunction with sensory, motor or cognitive events (event-related potentials). Evoked responses reflect the basic physiology of sensory processes, while event-related potentials combine the time/space resolution of electrophysiologic signals with the specificity of eliciting neuropsychological conditions. The rationale for investigating drug effects on evoked and event-related potentials is manifold. Both are related to sensory and operant behavior and under suitable experimental conditions allow interpretation of drug-related changes in terms of CNS excitability. Some continuity between observations in man and in vivo or in vitro animal data is often possible. Proper handling of the stimulus physical properties or experimental/situational links may allow the responses to be related to sensory input or to neuropsychological manipulation of selectively activated CNS functions or functional subsystems and therefore to control spontaneous variability. This review summarizes today's knowledge of the application of electrophysiology to human neuropharmacology, with due reference to basic pharmacology and experimental evidence.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0379-0355
pubmed:author
pubmed:issnType
Print
pubmed:volume
24 Suppl C
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
41-50
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Stimulus- and event-related evoked potentials: from neuroscience to clinical neuropharmacology.
pubmed:affiliation
Center for Neuropsychoactive Drugs, Department of Motor Science and Rehabilitation, University of Genoa, Genoa, Italy.
pubmed:publicationType
Journal Article, Review