Linked Life Data

12574959

Source:http://linkedlifedata.com/resource/pubmed/id/12574959

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-2-7
pubmed:abstractText
Angiogenesis plays an important role in multiple myeloma (MM) progression. Various mitogens such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (FGF-2) have been implicated in the angiogenic process of various malignancies. Interleukin-6 (IL-6) is a growth factor of myeloma cells and its signaling is mediated via a cell surface receptor complex (IL-6r). IL-6 and tumor necrosis factor-alpha (TNF-alpha) are involved in the secretion of VEGF by IL-6r expressing myeloma cells. In this study, serum FGF-2, VEGF, IL-6r, and TNF-alpha were measured in 46 untreated MM patients and were studied in relation to disease stage (by Salmon-Durie criteria) and severity [assessed by serum beta(2)-microglobulin (beta(2)M), C-reactive protein (CRP), alpha(1)-antitrypsin (alpha(1)AT), and lactic dehydrogenase (LDH) levels]. The results showed that FGF-2, VEGF, IL-6r, and TNF-alpha were significantly elevated in MM patients in comparison to controls ( p<0.008) and were significantly higher in stage III disease in comparison to stages I and II ( p<0.03). The mean concentrations of IL-6r were 877+/-374, 1220+/-308, 1431+/-878, and 453+/-180 pg/ml for stages I, II, and III and controls, respectively. Levels of beta(2)M, alpha(1)AT, CRP, and LDH were all significantly higher in MM patients than controls and increased with advancing stage of disease. There were positive correlations of both VEGF and FGF-2 with IL-6r, TNF-alpha, beta(2)M, alpha(1)AT, CRP, and LDH. We conclude that IL-6r and TNF-alpha increase in parallel to VEGF and FGF-2 with increasing stage of MM disease. These molecules correlate with biochemical markers of disease activity and may play a role in the progression of multiple myeloma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0939-5555
pubmed:author
pubmed:issnType
Print
pubmed:volume
82
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19-23
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed-meshheading:12574959-Adult, pubmed-meshheading:12574959-Aged, pubmed-meshheading:12574959-Aged, 80 and over, pubmed-meshheading:12574959-Biological Markers, pubmed-meshheading:12574959-Case-Control Studies, pubmed-meshheading:12574959-Endothelial Growth Factors, pubmed-meshheading:12574959-Female, pubmed-meshheading:12574959-Fibroblast Growth Factor 2, pubmed-meshheading:12574959-Humans, pubmed-meshheading:12574959-Intercellular Signaling Peptides and Proteins, pubmed-meshheading:12574959-Lymphokines, pubmed-meshheading:12574959-Male, pubmed-meshheading:12574959-Middle Aged, pubmed-meshheading:12574959-Multiple Myeloma, pubmed-meshheading:12574959-Neovascularization, Pathologic, pubmed-meshheading:12574959-Prognosis, pubmed-meshheading:12574959-Receptors, Interleukin-6, pubmed-meshheading:12574959-Severity of Illness Index, pubmed-meshheading:12574959-Solubility, pubmed-meshheading:12574959-Tumor Necrosis Factor-alpha, pubmed-meshheading:12574959-Vascular Endothelial Growth Factor A, pubmed-meshheading:12574959-Vascular Endothelial Growth Factors
pubmed:year
2003
pubmed:articleTitle
Relationship between circulating serum soluble interleukin-6 receptor and the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in multiple myeloma.
pubmed:affiliation
Department of Hematology, University Hospital of Heraklion, P.O. Box 1352 Heraklion, Crete, Greece. freda@med.uoc.gr
pubmed:publicationType
Journal Article