Linked Life Data

12574866

Source:http://linkedlifedata.com/resource/pubmed/id/12574866

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-2-7
pubmed:databankReference
pubmed:abstractText
The D. melanogaster rst and kirre genes encode two highly related immunoglobulin-like cell adhesion molecules that function redundantly during embryonic muscle development. The two genes appear to be derived from a common ancestor by gene duplication. Gene duplications have been proposed to be of major evolutionary significance since duplicated redundant sequences can accumulate mutations without detrimental effects for the organism and leave the duplicated genes free to assume novel functions. To address the issue of conservation of the duplicated sequences and their putative redundancy, as well as to identify putative functional divergence of the paralogs during drosophilid evolution, we performed an interspecies comparison of the rst and kirre genes from D. virilis and D. melanogaster. The D. virilis genome contains orthologues of both rst and kirre and hence the duplication took place before the split of the two lineages and has subsequently been conserved. However, whilst the Rst orthologues show a high degree of sequence similarity, this similarity is lower in Kirre orthologues. Especially the intracellular domains of D. virilis and D. melanogaster Kirre sequences are highly divergent: the D. virilis kirre gene lacks the 3'-most exon present in D. melanogaster, which contains motifs conserved between kirre and rst in D. melanogaster. Hence, while each of the two genes is highly conserved at the level of its exon-intron organization, the selection forces acting on the rst and kirre coding sequences are different. These findings are discussed in the light of general evolutionary mechanisms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-2844
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
187-97
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:12574866-Amino Acid Sequence, pubmed-meshheading:12574866-Animals, pubmed-meshheading:12574866-Biological Evolution, pubmed-meshheading:12574866-Cell Adhesion Molecules, Neuronal, pubmed-meshheading:12574866-Cloning, Molecular, pubmed-meshheading:12574866-Conserved Sequence, pubmed-meshheading:12574866-Drosophila, pubmed-meshheading:12574866-Drosophila Proteins, pubmed-meshheading:12574866-Drosophila melanogaster, pubmed-meshheading:12574866-Exons, pubmed-meshheading:12574866-Eye Proteins, pubmed-meshheading:12574866-Gene Duplication, pubmed-meshheading:12574866-Introns, pubmed-meshheading:12574866-Membrane Proteins, pubmed-meshheading:12574866-Molecular Sequence Data, pubmed-meshheading:12574866-Muscle Proteins, pubmed-meshheading:12574866-Protein Structure, Tertiary, pubmed-meshheading:12574866-Sequence Homology, Amino Acid
pubmed:year
2003
pubmed:articleTitle
Interspecies comparison of a gene pair with partially redundant function: the rst and kirre genes in D. virilis and D. melanogaster.
pubmed:affiliation
Institut für Biologie III, Albert-Ludwigs-Universität, Schänzlestrasse 1, D-79104, Freiburg im Breisgau, Germany.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't