Source:http://linkedlifedata.com/resource/pubmed/id/12570740
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2003-2-6
|
| pubmed:abstractText |
The three-dimensional structures of Haemophilus influenzae proteins whose biological functions are unknown are being determined as part of a structural genomics project to ask whether structural information can assist in assigning the functions of proteins. The structures of the hypothetical proteins are being used to guide further studies and narrow the field of such studies for ultimately determining protein function. An outline of the structural genomics methodological approach is provided along with summaries of a number of completed and in progress crystallographic and NMR structure determinations. With more than twenty-five structures determined at this point and with many more in various stages of completion, the results are encouraging in that some level of functional understanding can be deduced from experimentally solved structures. In addition to aiding in functional assignment, this effort is identifying a number of possible new targets for drug development.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1568-0053
|
| pubmed:author |
pubmed-author:AliG MGM,
pubmed-author:BonanderNicklasN,
pubmed-author:EisensteinEdwardE,
pubmed-author:F ParsonsJamesJ,
pubmed-author:FisherKathryn EKE,
pubmed-author:GillilandGary LGL,
pubmed-author:HerzbergOsnatO,
pubmed-author:HowardAndrew JAJ,
pubmed-author:HuangKuiK,
pubmed-author:KrajewskiWojiechW,
pubmed-author:LadnerJaneJ,
pubmed-author:MelamudEugeneE,
pubmed-author:MoultJohnJ,
pubmed-author:ObmolovaGalinaG,
pubmed-author:OrbanJohnJ,
pubmed-author:ParsonsLisaL,
pubmed-author:RaoC VCV,
pubmed-author:ReddyPrasadP,
pubmed-author:TempczykAleksandraA,
pubmed-author:TeplyakovAlexeyA,
pubmed-author:ThankiNarmadaN,
pubmed-author:ToedtJohnJ,
pubmed-author:TordovaMariaM,
pubmed-author:YehDeok CheonDC,
pubmed-author:ZhangHongH,
pubmed-author:ZhongLiL
|
| pubmed:issnType |
Print
|
| pubmed:volume |
2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
339-53
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading | |
| pubmed:year |
2002
|
| pubmed:articleTitle |
Assisting functional assignment for hypothetical Heamophilus influenzae gene products through structural genomics.
|
| pubmed:affiliation |
Center for Advanced Research in Biotechnology of the University of Maryland Biotechnology Institute and the National Institute of Standards and Technology, 9600 Gudelsky Drive, Rockville, MD 20850, USA. gary.gilliland@nist.gov
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Review,
Research Support, Non-U.S. Gov't
|