12570304

Source:http://linkedlifedata.com/resource/pubmed/id/12570304

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0011923, umls-concept:C0016315, umls-concept:C0456603, umls-concept:C0871935, umls-concept:C1261322
pubmed:issue	2
pubmed:dateCreated	2003-2-6
pubmed:abstractText	We deduce the signal-to-noise ratio for fluorescence lifetime imaging when using frequency-domain methods. We assume mono-exponential decay and quantum-noise-limited performance. The results are compared with Monte Carlo simulations with good agreement. We also compare our results with previous investigations of time-domain methods for fluorescence lifetime imaging. For a given number of detected photons, we find that frequency-domain and time-domain methods are equally good. The correct choice of detection technique and its parameters is important for obtaining good results.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9800943
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	1084-7529
pubmed:author	pubmed-author:CarlssonKjellK, pubmed-author:PhilipJohanJ
pubmed:issnType	Print
pubmed:volume	20
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	368-79
pubmed:meshHeading	pubmed-meshheading:12570304-Computer Simulation, pubmed-meshheading:12570304-Microscopy, Fluorescence, pubmed-meshheading:12570304-Models, Theoretical, pubmed-meshheading:12570304-Monte Carlo Method
pubmed:year	2003
pubmed:articleTitle	Theoretical investigation of the signal-to-noise ratio in fluorescence lifetime imaging.
pubmed:affiliation	Department of Mathematics, The Royal Institute of Technology, SE-100 44 Stockholm, Sweden. johanph@math.kth.se
pubmed:publicationType	Journal Article