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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-2-5
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pubmed:abstractText |
1 The present study investigated the effects of the preferential beta(3)-AR agonist BRL 37344 (BRL) on force of contraction (FOC), Ca(2+)-transient and eNOS-activity in human right atrial myocardium. 2 BRL concentration-dependently caused an increase in FOC that was paralleled by an increase in Ca(2+)-transient and a shortening of time to half peak relaxation (T0.5T). These effects were abolished in the presence of propranolol (0.3 micro M). 3 BRL acted as a competitive antagonist towards isoprenaline and in binding experiments it was shown to have a distinct affinity towards beta(1/2)-AR. 4 In immunohistochemical experiments BRL (10 micro M) increased detection of activated eNOS. This effect remained constant in the presence of propranolol (0.3 micro M). 5 BRL increased directly detected NO in DAF-staining experiments. This increase was significantly smaller in the presence of the NO-inhibitor L-NAME. 6 The inotropic effects of BRL were not changed in the presence of L-NMA. 7 These results suggest that the inotropic effects of BRL in human atrium are mediated via beta(1/2)-AR, whereas the increase of atrial eNOS-activity is due to beta(3)- adrenergic stimulation. This increase in eNOS-activity did not influence atrial myocardial contractility. In conclusion, this study shows that beta(3)-adrenergic stimulation is present in human atrium, but may not be functionally as significant as in the left ventricle.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-10411579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-10557026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-10690339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-11112265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-11273992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-11485370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-11498519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-1309621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-1361569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-1657613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-1680716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-1970536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-1974371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-2155496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-2905184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-6325935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-7520443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-7557816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-7788902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-7883990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-7905532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-7908057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-7912539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-8095462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-8258999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-8736774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-8755668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-8781470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-8820105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-8864547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-9262464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-9618411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-9666719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-9703994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12569077-9769330
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/BRL 37344,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Ethanolamines,
http://linkedlifedata.com/resource/pubmed/chemical/NOS3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/Propranolol,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta-1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta-3
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
138
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
521-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12569077-Humans,
pubmed-meshheading:12569077-Myocardium,
pubmed-meshheading:12569077-Calcium,
pubmed-meshheading:12569077-Aged,
pubmed-meshheading:12569077-Ethanolamines,
pubmed-meshheading:12569077-Female,
pubmed-meshheading:12569077-Male,
pubmed-meshheading:12569077-Fluorometry,
pubmed-meshheading:12569077-Enzyme Induction,
pubmed-meshheading:12569077-Heart Atria,
pubmed-meshheading:12569077-Propranolol,
pubmed-meshheading:12569077-Dose-Response Relationship, Drug,
pubmed-meshheading:12569077-Adrenergic beta-Antagonists,
pubmed-meshheading:12569077-Adrenergic beta-Agonists,
pubmed-meshheading:12569077-Immunohistochemistry,
pubmed-meshheading:12569077-Receptors, Adrenergic, beta,
pubmed-meshheading:12569077-Nitric Oxide Synthase,
pubmed-meshheading:12569077-Receptors, Adrenergic, beta-1,
pubmed-meshheading:12569077-Receptors, Adrenergic, beta-2,
pubmed-meshheading:12569077-Receptors, Adrenergic, beta-3
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