|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2003-2-4
|
|
pubmed:abstractText |
The inverse relationship between serum albumin concentration and its half-life suggested to early workers that albumin would be protected from a catabolic fate by a receptor-mediated mechanism much like that proposed for IgG. We show here that albumin binds FcRn in a pH dependent fashion, that the lifespan of albumin is shortened in FcRn-deficient mice, and that the plasma albumin concentration of FcRn-deficient mice is less than half that of wild-type mice. These results affirm the hypothesis that the major histocompatibility complex-related Fc receptor protects albumin from degradation just as it does IgG, prolonging the half-lives of both.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-10837074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-10886402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-10933786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-11207281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-1127526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-11567626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-11741917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-13488251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-1530991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-2112266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-2146275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-2606142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-2646699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-2911353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-3989700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-4186070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-637870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-7868883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-7889418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-8088452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-8316860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-8605939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-8643606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-8696333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-885588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-8871627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-9014824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-9048207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12566415-9786428
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0022-1007
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
3
|
|
pubmed:volume |
197
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
315-22
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:12566415-Animals,
pubmed-meshheading:12566415-CHO Cells,
pubmed-meshheading:12566415-Cattle,
pubmed-meshheading:12566415-Cricetinae,
pubmed-meshheading:12566415-Half-Life,
pubmed-meshheading:12566415-Histocompatibility Antigens Class I,
pubmed-meshheading:12566415-Hydrogen-Ion Concentration,
pubmed-meshheading:12566415-Immunoglobulin G,
pubmed-meshheading:12566415-Major Histocompatibility Complex,
pubmed-meshheading:12566415-Mice,
pubmed-meshheading:12566415-Mice, Inbred C57BL,
pubmed-meshheading:12566415-Mice, Knockout,
pubmed-meshheading:12566415-Protein Binding,
pubmed-meshheading:12566415-Rats,
pubmed-meshheading:12566415-Receptors, Fc,
pubmed-meshheading:12566415-Recombinant Proteins,
pubmed-meshheading:12566415-Serum Albumin, Bovine
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan.
|
|
pubmed:affiliation |
Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
