rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
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pubmed:dateCreated |
2003-2-4
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pubmed:abstractText |
Paclitaxel conjugates of 7-phenylacetamidocephalosporanic acid were prepared as prodrugs for site specific activation by targeted beta-lactamase. Immunologically specific activation of the prodrug 5 containing 3,3-dimethyl-4-amino-butyric acid as linker in combination with the fusion protein L-49-sFv-beta-lactamase was demonstrated in vitro on 3677 melanoma cells.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic,
http://linkedlifedata.com/resource/pubmed/chemical/Cephalosporins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Indicators and Reagents,
http://linkedlifedata.com/resource/pubmed/chemical/L49-sFv-beta-lactamase,
http://linkedlifedata.com/resource/pubmed/chemical/Paclitaxel,
http://linkedlifedata.com/resource/pubmed/chemical/Prodrugs,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/beta-Lactamases
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
|
pubmed:issn |
0960-894X
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
10
|
pubmed:volume |
13
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
539-42
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12565967-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:12565967-Cephalosporins,
pubmed-meshheading:12565967-Chromatography, High Pressure Liquid,
pubmed-meshheading:12565967-Cyclization,
pubmed-meshheading:12565967-Enzyme Inhibitors,
pubmed-meshheading:12565967-Half-Life,
pubmed-meshheading:12565967-Humans,
pubmed-meshheading:12565967-Immunoglobulin G,
pubmed-meshheading:12565967-Indicators and Reagents,
pubmed-meshheading:12565967-Melanoma, Experimental,
pubmed-meshheading:12565967-Paclitaxel,
pubmed-meshheading:12565967-Prodrugs,
pubmed-meshheading:12565967-Recombinant Fusion Proteins,
pubmed-meshheading:12565967-Structure-Activity Relationship,
pubmed-meshheading:12565967-Tumor Cells, Cultured,
pubmed-meshheading:12565967-beta-Lactamases
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pubmed:year |
2003
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pubmed:articleTitle |
Cephalosporin prodrugs of paclitaxel for immunologically specific activation by L-49-sFv-beta-lactamase fusion protein.
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pubmed:affiliation |
Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA. vivekananda.vrudhula@bms.com
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pubmed:publicationType |
Journal Article,
In Vitro
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