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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-2-4
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pubmed:abstractText |
A lead discovery library and a follow-up focused library of alpha-acylaminoketones were designed based on known dibenzoylhydrazine ecdysone agonists, including GS(TM)-E. The compounds were assayed in mammalian cells expressing the ecdysone receptor from Bombyx mori for their ability to cause expression of a reporter gene downstream of an ecdysone response element. The most potent alpha-acylaminoketones were comparable to GS(TM)-E in this assay.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
475-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12565954-Amines,
pubmed-meshheading:12565954-Animals,
pubmed-meshheading:12565954-Bombyx,
pubmed-meshheading:12565954-Cells, Cultured,
pubmed-meshheading:12565954-Ecdysone,
pubmed-meshheading:12565954-Gene Expression,
pubmed-meshheading:12565954-Indicators and Reagents,
pubmed-meshheading:12565954-Ketones,
pubmed-meshheading:12565954-Lethal Dose 50,
pubmed-meshheading:12565954-Mice,
pubmed-meshheading:12565954-Molecular Conformation,
pubmed-meshheading:12565954-Receptors, Steroid,
pubmed-meshheading:12565954-Structure-Activity Relationship,
pubmed-meshheading:12565954-beta-Galactosidase
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pubmed:year |
2003
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pubmed:articleTitle |
Synthesis and SAR of alpha-acylaminoketone ligands for control of gene expression.
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pubmed:affiliation |
RHeoGene, PO Box 949, 727Norristown Road, Spring House, PA 19477-0949, USA. ctice@rheogene.com
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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