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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-2-4
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pubmed:abstractText |
Benzyloxyphenethylpiperazines are a new class of high affinity NK1 receptor antagonists. Oral bioavailability and selectivity can be fine tuned by the nature of the substituents on the basic nitrogen atom. Addition of substituents with a carboxylic acid group led to very selective and orally active NK1 antagonists free of interaction with L-type calcium channels.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:ChristopheBB,
pubmed-author:CollartPP,
pubmed-author:GenicotCC,
pubmed-author:GillardMM,
pubmed-author:GoossensLL,
pubmed-author:HénichartJ-PJP,
pubmed-author:LassoieM-AMA,
pubmed-author:MoureauFF,
pubmed-author:NeuwelsMM,
pubmed-author:NicolasJ-MJM,
pubmed-author:PasauPP,
pubmed-author:QuéréLL,
pubmed-author:RyckmansTT,
pubmed-author:StiernetFF,
pubmed-author:TavernaPP,
pubmed-author:Van KeulenB JBJ
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
437-42
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12565946-Acylation,
pubmed-meshheading:12565946-Alkylation,
pubmed-meshheading:12565946-Animals,
pubmed-meshheading:12565946-Biological Availability,
pubmed-meshheading:12565946-CHO Cells,
pubmed-meshheading:12565946-Carboxylic Acids,
pubmed-meshheading:12565946-Chemistry, Physical,
pubmed-meshheading:12565946-Cricetinae,
pubmed-meshheading:12565946-Crystallography, X-Ray,
pubmed-meshheading:12565946-Guinea Pigs,
pubmed-meshheading:12565946-Humans,
pubmed-meshheading:12565946-Indicators and Reagents,
pubmed-meshheading:12565946-Models, Molecular,
pubmed-meshheading:12565946-Molecular Conformation,
pubmed-meshheading:12565946-Nitrogen,
pubmed-meshheading:12565946-Physicochemical Phenomena,
pubmed-meshheading:12565946-Piperazines,
pubmed-meshheading:12565946-Pulmonary Edema,
pubmed-meshheading:12565946-Receptors, Neurokinin-1,
pubmed-meshheading:12565946-Structure-Activity Relationship
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pubmed:year |
2003
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pubmed:articleTitle |
Discovery of orally bioavailable NK1 receptor antagonists.
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pubmed:affiliation |
Chemistry Department, UCB Pharma, Chemin du Foriest, B-1420, Braine-l'Alleud, Belgium. christophe.genicot@ucb-group.com
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pubmed:publicationType |
Journal Article
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