Source:http://linkedlifedata.com/resource/pubmed/id/12565945
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2003-2-4
|
| pubmed:abstractText |
A series of novel beta-amino acids has been synthesized and tested for their in vitro antifungal activity against Candida albicans. A steep SAR was observed. beta-Amino acid 21 (BAY 10-8888/PLD-118) revealed the most favourable activity-tolerability profile and was selected for clinical studies as a novel antifungal for the oral treatment of yeast infections.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
10
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
433-6
|
| pubmed:meshHeading |
pubmed-meshheading:12565945-Amino Acids,
pubmed-meshheading:12565945-Antifungal Agents,
pubmed-meshheading:12565945-Candida albicans,
pubmed-meshheading:12565945-Indicators and Reagents,
pubmed-meshheading:12565945-Microbial Sensitivity Tests,
pubmed-meshheading:12565945-Molecular Conformation,
pubmed-meshheading:12565945-Stereoisomerism,
pubmed-meshheading:12565945-Structure-Activity Relationship
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Novel antifungal beta-amino acids: synthesis and activity against Candida albicans.
|
| pubmed:affiliation |
Medicinal Chemistry, Business Group Pharma, Bayer AG, D-42096 Wuppertal, Germany. joachim.mittendorf.jm@bayer-ag.de
|
| pubmed:publicationType |
Journal Article
|