12565941

Source:http://linkedlifedata.com/resource/pubmed/id/12565941

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0205314, umls-concept:C0243072, umls-concept:C0456387, umls-concept:C0679622, umls-concept:C1257954
pubmed:issue	3
pubmed:dateCreated	2003-2-4
pubmed:abstractText	A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity. Rational structural modifications were applied to potent COX-2 inhibitors to obtain the desired pharmacokinetic profiles for improved oral anti-inflammatory activity.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents..., http://linkedlifedata.com/resource/pubmed/chemical/Benzopyrans, http://linkedlifedata.com/resource/pubmed/chemical/Carrageenan, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 1, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Indicators and Reagents, http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases, http://linkedlifedata.com/resource/pubmed/chemical/Ptgs1 protein, rat
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	0960-894X
pubmed:author	pubmed-author:ChungShinS, pubmed-author:HaJun-YongJY, pubmed-author:HoonChang HoonCH, pubmed-author:HyupYung HyupYH, pubmed-author:KangSeon-HwaSH, pubmed-author:KwanJin KwanJK, pubmed-author:KyuJin KyuJK, pubmed-author:MinKyung MinKM, pubmed-author:NohMin-SooMS
pubmed:issnType	Print
pubmed:day	10
pubmed:volume	13
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	413-7
pubmed:dateRevised	2008-11-21
pubmed:meshHeading	pubmed-meshheading:12565941-Animals, pubmed-meshheading:12565941-Anti-Inflammatory Agents, Non-Steroidal, pubmed-meshheading:12565941-Benzopyrans, pubmed-meshheading:12565941-Carrageenan, pubmed-meshheading:12565941-Chemistry, Physical, pubmed-meshheading:12565941-Cyclooxygenase 1, pubmed-meshheading:12565941-Cyclooxygenase 2, pubmed-meshheading:12565941-Cyclooxygenase 2 Inhibitors, pubmed-meshheading:12565941-Cyclooxygenase Inhibitors, pubmed-meshheading:12565941-Edema, pubmed-meshheading:12565941-Indicators and Reagents, pubmed-meshheading:12565941-Isoenzymes, pubmed-meshheading:12565941-Male, pubmed-meshheading:12565941-Membrane Proteins, pubmed-meshheading:12565941-Physicochemical Phenomena, pubmed-meshheading:12565941-Prostaglandin-Endoperoxide Synthases, pubmed-meshheading:12565941-Rats, pubmed-meshheading:12565941-Rats, Sprague-Dawley
pubmed:year	2003
pubmed:articleTitle	2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors.
pubmed:affiliation	Drug Discovery, AmorePacific Corporation R&D Center, 314-1 Bora-ri, Kiheung-eup, Yongin-si, Kyounggi-do 449-729, South Korea. yhjoo@pacific.co.kr
pubmed:publicationType	Journal Article